申请人:Warner-Lambert Company
公开号:US03957851A1
公开(公告)日:1976-05-18
The invention relates to 1-phenyl-4-amino-cyclohex-2-ene-1-carboxylic-acid-esters of the general formula I ##SPC1## wherein R.sub.1 and R.sub.2 may be the same or different and may be H, alkyl, hydroxyalkyl, alkenyl, preferably with 1 to 4 C-atoms, aralkyl which may be bonded to each other, in which connection the heterocyclic system formed may be substituted further by the OH-- group and where attachment takes place by an oxygen or a nitrogen atom, if desired, which in its turn carries an H, alkyl with 1 to 4 C-atoms, aryl which may be substituted by chlorine, preferably in 3 or 4-position, and by methoxy, preferably in 2 or 4-position, acyl, preferably alkanoyl with 1 to 4 C-atoms, and aroyl, or aralkyl, and R.sub.3 represents an alkyl radical with 1 to 4 C-atoms, the salts thereof and quarternary ammonium compounds, and a process for their preparation. These compounds have analgesic and neuroleptic properties.
该发明涉及一般式I的1-苯基-4-氨基-环己-2-烯-1-羧酸酯,其中R.sub.1和R.sub.2可以相同也可以不同,可以是H、烷基、羟基烷基、烯基,最好是具有1到4个碳原子的烷基、芳基烷基,它们可以相互连接,形成的杂环系统可以进一步被OH-基取代,连接可以通过氧原子或氮原子进行,如果需要的话,这些原子又可以携带一个氢、1到4个碳原子的烷基、芳基(可以被氯原子取代,最好在3或4位),以及甲氧基(最好在2或4位),酰基(最好是具有1到4个碳原子的烷酰基)和芳酰基,或芳基烷基,R.sub.3代表一个具有1到4个碳原子的烷基基团,其盐和季铵化合物,以及它们的制备方法。这些化合物具有镇痛和神经阻滞特性。