(2α,3β)-(+/-)-Tetrahydro-2,3-dimethylfuran | 16251-73-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 氧唑烯
• 英文名称: (2α,3β)-(+/-)-Tetrahydro-2,3-dimethylfuran
• 英文别名: trans-2-methyl-3-hydroxytetrahydrofuran；2,3-dimethyltetrahydrofuran；(2S,3R)-2,3-dimethyloxolane
• CAS: 16251-73-3；99488-08-1；99488-13-8
• 化学式: C₆H₁₂O
• 分子量: 100.161
• InChiKey: HIPLXTICEUKKIT-RITPCOANSA-N

物化性质

• 沸点：
  100.3±8.0 °C(Predicted)
• 密度：
  0.836±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  7
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  (2α,3β)-(+/-)-Tetrahydro-2,3-dimethylfuran 在 chromium(VI) oxide 、 乙酸酐 作用下， 以 苯 为溶剂， 反应 12.0h， 以63%的产率得到(3R,4S)-3,4-dimethylbutyrolactone
  参考文献：
  名称：

  Frauenrath, Herbert; Philipps, Thomas, Liebigs Annalen der Chemie, 1985, # 10, p. 1951 - 1961

  摘要：

  DOI：
• 作为产物：
  描述：

  2,3-二氢-5-甲基呋喃 在 sodium hydroxide 、 dimethyl sulfide borane 、 双氧水 作用下， 生成 (2α,3β)-(+/-)-Tetrahydro-2,3-dimethylfuran
  参考文献：
  名称：

  Hydroboration. 71. Hydroboration of representative heterocyclic olefins with borane-methyl sulfide, 9-borabicyclo[3.3.1]nonane, dicyclohexylborane, and disiamylborane. Synthesis of heterocyclic alcohols

  摘要：

  DOI：

  10.1021/jo00210a004

文献信息

• HETEROCYCLIC TRIAZOLE COMPOUNDS AS AGONISTS OF THE APJ RECEPTOR
  申请人：AMGEN INC.

  公开号：US20170320860A1

  公开（公告）日：2017-11-09

  Compounds of Formula I and Formula II, pharmaceutically acceptable salts thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the following structures: where the definitions of the variables are provided herein.

  公式I和公式II的化合物，其药用盐，上述任何一个的立体异构体，或它们的混合物是APJ受体的激动剂，可能用于治疗心血管和其他疾病。公式I和公式II的化合物具有以下结构： 其中变量的定义在此提供。
• [EN] NTCP INHIBITORS<br/>[FR] INHIBITEURS DE NTCP
  申请人：NAT INSTITUTE OF BIOLOGICAL SCIENCES BEIJING

  公开号：WO2019196953A1

  公开（公告）日：2019-10-17

  Provided are cyclosporin A analogues that are NTCP inhibitors and useful for treating HBV and/or HDV infection (s), hepatoprotection and amelioration of hypercholesterolemia, diabetes and inhibiting cancer.

  提供的环孢霉素A类似物是NTCP抑制剂，可用于治疗HBV和/或HDV感染，肝脏保护和改善高胆固醇血症、糖尿病以及抑制癌症。
• Synthesis of 1,2,3-Trisubstituted Pyrrolidines and 2,3-Disubstituted Tetrahydrofurans via Diastereoselective Reductive Cyclization of γ-Chloroimines and γ-Chloroketones
  作者：Norbert De Kimpe、Mudiganti Sastry、Sven Mangelinckx、Bart Lucas

  DOI：10.1055/s-0031-1289544

  日期：2011.12

  involves reductive cyclization of gamma-chloroketimines, which were generated in situ from the reaction of 3-substituted 5-chloro-2-pentanones and a primary amine. Various reduction conditions were explored to induce a diastereoselective reductive cyclization. 2,3-Disubstituted tetrahydrofurans were obtained by the direct reduction of 3-substituted 5-chloro-2-pentanones with sodium borohydride.

  描述了一种新的非对映选择性合成方法，用于 1,2,3-三取代吡咯烷和 2,3-二取代四氢呋喃。吡咯烷的合成涉及γ-氯酮亚胺的还原环化，γ-氯酮亚胺是由3-取代的5-氯-2-戊酮和伯胺反应原位生成的。探索了各种还原条件以诱导非对映选择性还原环化。2,3-二取代的四氢呋喃是通过用硼氢化钠直接还原 3-取代的 5-氯-2-戊酮获得的。
• CYCLOSPORIN DERIVATIVES WHEREIN THE MEBMT SIDECHAIN HAS BEEN CYCLIZED
  申请人：Allergan, Inc.

  公开号：US20160200767A1

  公开（公告）日：2016-07-14

  The present invention relates to cyclosporin analogs that are potent inhibitors of cyclophilin D and have low immunosuppressive activity; processes for preparing them; pharmaceutical compositions containing them; and methods for using these analogs and compositions containing them for the treatment of medical conditions, including but not limited to ischemic conditions, such as ischemia-reperfusion (I/R) injury, including myocardial FR injury, cerebral I/R injury, and ocular or retinal I/R injury.
• ENANTIOMERICALLY ENRICHED, POLYCRYSTALLINE MOLECULAR SIEVES
  申请人：CALIFORNIA INSTITUTE OF TECHNOLOGY

  公开号：US20180207625A1

  公开（公告）日：2018-07-26

  This disclosure describes enantiomerically enriched chiral molecular sieves and methods of making and using the same. In some embodiments, the molecular sieves are silicates or germanosilicates of STW topology.