tris-(m-tolyl)antimony(V) dibromide | 61184-34-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: tris-(m-tolyl)antimony(V) dibromide
• 英文别名: tris(3-methylphenyl)antimony dibromide；(3-CH3C6H4)3SbBr2；Dibromotris(3-methylphenyl)-lambda~5~-stibane；dibromo-tris(3-methylphenyl)-λ5-stibane
• CAS: 61184-34-7
• 化学式: C₂₁H₂₁Br₂Sb
• 分子量: 554.956
• InChiKey: MQMXQLWAGGROTC-UHFFFAOYSA-L

计算性质

• 辛醇/水分配系数(LogP)：
  4.82
• 重原子数：
  24
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  0
• 氢给体数：
  0
• 氢受体数：
  0

反应信息

• 作为反应物：
  描述：

  tris-(m-tolyl)antimony(V) dibromide 、 3,4,5-trimethoxybenzoic acid potassium salt 以 甲苯 为溶剂， 反应 12.0h， 以86%的产率得到bis-(3,4,5-trimethoxybenzoato)tris-(m-tolyl)-antimony(V)
  参考文献：
  名称：

  Anti-leishmanial activity of heteroleptic organometallic Sb(v) compounds

  摘要：

  在为治疗寄生虫疾病利什曼病寻找新药物的过程中，合成、表征并评估了一系列具有[SbR3(O2CR′)2]形式的金属有机锑(V)二羧酸盐。这些配合物中的金属有机部分（R）包括苯基、甲基苯基（邻、间或对位）或苄基。羧酸盐主要为取代苯甲酸盐，部分化合物包含乙酸根或肉桂酸根配体。测定了[Sb(p-Tol)3(O2CC6H2-3,4,5-(OMe)3)2]·0.5PhMe和[SbPh3(m-CH3C6H4CH2CO2)2]的晶体结构，显示它们采用典型的三角锥几何构型，为单体结构，有五配位的锑中心。总共评估了26种锑(V)化合物的生物活性，针对利什曼原虫Leishmania major以及人类成纤维皮肤细胞，以衡量其普遍毒性。其中，11种化合物（主要是含间位或对位甲基苯基配体的取代苯甲酸盐）在0.5至3.5 μM浓度下对寄生虫的无鞭毛体显示出高度效果，并且在低于25 μM的浓度下对哺乳动物细胞无毒，使其成为极具前景的药物候选物。

  DOI：

  10.1039/c3dt51382c
• 作为产物：
  描述：

  3-溴甲基苯 在 sodium 、 Br₂ 作用下， 以 乙醚 、 苯 为溶剂， 生成 tris-(m-tolyl)antimony(V) dibromide
  参考文献：
  名称：

  Michaelis, A.; Genzken, U., Liebigs Annalen der Chemie, 1887, vol. 242, p. 164 - 188

  摘要：

  DOI：

文献信息

• Solid-state structures of triarylantimony dihalides; the isolation of some mixed-halide species and crystal structures of Ph3SbI2 and [Ph4Sb]I3
  作者：Neil Bricklebank、Stephen M. Godfrey、Helen P. Lane、Charles A. McAuliffe、Robin G. Pritchard

  DOI：10.1039/dt9940001759

  日期：——

  it to be a distorted trigonal-bipyramidal molecule. The distortion from regular trigonal-bipyramidal geometry may be explained by a pseudorotation process towards a rectangular pyramid. Moreover, there are two independent molecules within the unit cell and its distorted structure is in direct contrast to the known Ph3SbX2(X = Cl or Br) which both adopt regular trigonal-bipyramidal geometry. The interhalogen

  合成了十五种化学计量为R 3 SbX 2的化合物（R = Ph或取代的芳基； X 2 = Br 2，I 2或IBr），并通过拉曼光谱法进行了研究。已经确定了Ph 3 SbI 2的晶体结构，表明它是扭曲的三角双锥体分子。可以通过朝向矩形金字塔的伪旋转过程来解释来自规则的三角双锥几何形状的变形。此外，在晶胞内有两个独立的分子，其扭曲的结构与已知的Ph 3 SbX 2直接相反。（X = Cl或Br）都采用规则的三角双锥几何形状。卤素间化合物R 3 SbIBr也具有三角-双锥体的几何形状。与在溶液中电离形成[Ph 3 EI] I的分子Ph 3 EI 2（E = P或As）形成鲜明对比的是，Ph 3 SbI 2在乙腈溶液中发生化学变化并形成离子型[Ph 4 Sb] I 3，没有[Ph 3 SbI] I的证据。还已经确定了[Ph 4 Sb] I 3的晶体结构。
• Reaction of Triarylantimony Dibromides Ar3SbBr2 with Sodium Salts (X = NO3, NCS, F)
  作者：V. V. Sharutin、O. K. Sharutina、D. M. Sopshina

  DOI：10.1134/s1070363221090152

  日期：2021.9

  Abstract Triarylantimony dibromides reacted with sodium nitrate, thiocyanate, and fluoride in aqueous acetone at room temperature to give bridged dinuclear antimony compounds [(4-MeC6H4)3SbONO2]2O, (Ph3SbNCS)2O, [(3-MeC6H4)3SbNCS]2O, and [(4-MeC6H4)3SbNCS]2O and mononuclear derivatives (2-MeC6H4)3Sb(NCS)2 and (3-FC6H4)3SbF2. The antimony atoms in these compounds have a distorted trigonal-bipyramidal

  摘要 三芳基二溴化锑在室温下在丙酮水溶液中与硝酸钠、硫氰酸盐和氟化物反应，得到桥连的双核锑化合物 [(4-MeC 6 H 4 ) 3 SbONO 2 ] 2 O, (Ph 3 SbNCS) 2 O, [(3 -MeC 6 H 4 ) 3 SbNCS] 2 O 和 [(4-MeC 6 H 4 ) 3 SbNCS] 2 O 和单核衍生物 (2-MeC 6 H 4 ) 3 Sb(NCS) 2和 (3-FC 6 ^ h 4) 3 SbF 2。这些化合物中的锑原子具有扭曲的三角双锥构型，在轴向位置具有带负电的原子。
• Synthesis, crystal structures and in vitro antitumor activities of some arylantimony derivatives of analogues of demethylcantharimide
  作者：Guo-Cang Wang、Jian Xiao、Lin Yu、Jin-Shan Li、Jing-Rong Cui、Rui-Qing Wang、Fu-Xiang Ran

  DOI：10.1016/j.jorganchem.2004.02.015

  日期：2004.5

  A series of novel aylantimony derivatives of analogues of demethylcantharimide with the formulae ArnSbL(5-n) and ArnSbL'((5-n))(LH = N-hydroxy-demethyldehydrogencantharimide, L'H = N-hydroxy-demethyleantharimide, n = 3, 4; Ar=C6H5, 4CH(3)C(6)H(4), 3-CH3C6H4, 2-CH3C6H4, 4-ClC6H4, 4-FC6H4) were synthesized and characterized by elemental analysis, IR, 1 H NMR and mass spectroscopy. The crystal structures of (C6H5)(4)SbL, (4-CH3C6H4)(3)SbL2 and (3-CHC6H4)(3)SbL'(2) were determined by X-ray diffraction. The in vitro antitumor activities of all compounds against six cancer cells are reported. (C) 2004 Elsevier B.V. All rights reserved.
• Synthesis, characterization and antitumor activity of some arylantimony triphenylgermanylpropionates and crystal structures of Ph3GeCH(Ph)CH2CO2SbPh4 and [Ph3GeCH2CH(CH3)CO2]2Sb(4-ClC6H4)3
  作者：Yongqiang Ma、Jinshan Li、Zhenai Xuan、Runchang Liu

  DOI：10.1016/s0022-328x(00)00799-3

  日期：2001.2

  A series of novel arylantimony(V) triphenylgermanylpropionates with the formula ((Ph3GeCHRCHRCO2)-C-1-C-2)(n)SbAr(5-n) (R-1 = H, Ph; R-2 =H, CH3; n = 1, 2) were synthesized and characterized by elemental analysis, IR, H-1-NMR, C-13-NMR and mass spectroscopy. The crystal structures of Ph3GeCH(Ph)CH2CO2SbPh4 and [Ph3GeCH2CH(CH3)CO2](2)Sb(4-ClC6H4)(3) were determined by X-ray diffraction. The in vitro antitumor activities of some selected compounds against five cancer cells are reported. (C) 2001 Elsevier Science B.V. All rights reserved.
• Synthesis, characterization and structure of some arylantimony ferrocenylacrylates
  作者：Jin-Shan Li、Run-Chang Liu、Xin-Bao Chi、Guo-Cang Wang、Qun-Shen Guo

  DOI：10.1016/j.ica.2003.12.012

  日期：2004.5

  A series of arylantimony ferrocenylacrylates with the formula (C5H5FeC5H4CH=CHCO2)(n)SbAr(5-n) (n = 1, 2; Ar = C6H5, 4-CH3C6H4, 3-CH3C6H4, 2-CH3C6H4, 4-FC6H4) have been synthesized and characterized by elemental analysis, IR, H-1 NMR and mass spectra. The crystal structures of C5H5FeC5H4CH=CHCO2Sb(C6H5)(4) (I-1) and (C5H5FeC5H4CH=CHCO2)(2)Sb(C6H5)(3) (II1) have been determined by X-ray diffraction. (C) 2003 Elsevier B.V. All rights reserved.