4-(4-aminobenzyl)phenol | 97599-94-5

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 4-(4-aminobenzyl)phenol
• 英文别名: 4-((4-aminophenyl)methyl)phenol；4-Amino-4'-hydroxy-diphenylmethan；4-(4-hydroxybenzyl)aniline；4-[(4-aminophenyl)methyl]phenol
• CAS: 97599-94-5
• 化学式: C₁₃H₁₃NO
• mdl: MFCD08458837
• 分子量: 199.252
• InChiKey: DULOMPJDZXQPSM-UHFFFAOYSA-N

物化性质

• 熔点：
  151-151.5 °C
• 沸点：
  389.7±22.0 °C(Predicted)
• 密度：
  1.175±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  15
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.076
• 拓扑面积：
  46.2
• 氢给体数：
  2
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  4-(4-aminobenzyl)phenol 在 甲醇 、 sodium hydroxide 作用下， 生成 N-(4-(4-methoxybenzyl)phenyl)acetamide
  参考文献：
  名称：

  Substituted 4-Aminodiphenylmethanes¹

  摘要：

  DOI：

  10.1021/ja01216a052
• 作为产物：
  描述：

  N-乙酰基-4,4'-二氨基二苯基甲烷 生成 4-(4-aminobenzyl)phenol
  参考文献：
  名称：

  Substituted 4-Aminodiphenylmethanes¹

  摘要：

  DOI：

  10.1021/ja01216a052

文献信息

• Synthesis and reactions of chroman-2-ols and their benzo analogs with N-nucleophiles
  作者：Irina А. Semenova、Kirill S. Korzhenko、Dmitry V. Osipov、Vitaly А. Osyanin、Yuri N. Klimochkin

  DOI：10.1007/s10593-020-02661-0

  日期：2020.3

  By the action of acetic acid on 2-morpholinochromanes, a series of chroman-2-ols were obtained in which the hydroxyl group is easily substituted by a primary or secondary amine or benzyl carbamate fragments. In the case of hydrazines and hydrazides of carboxylic acids, the corresponding hydrazones are isolated.

  通过乙酸对2-吗啉代苯并二氢吡喃的作用，获得了一系列的苯并二氢吡喃-2-醇，其中羟基容易被伯胺或仲胺或氨基甲酸苄酯片段取代。在肼和羧酸的酰肼的情况下，分离出相应的。
• 2-Thiohydantoine derivative compounds and use thereof for the treatment of diabetes
  申请人：Binet Jean

  公开号：US20060025589A1

  公开（公告）日：2006-02-02

  The invention relates to 2-thiohydantoin compounds selected from compounds of general formula (I): in which, in particular, one of the radicals R 1 and R 2 comprises two aromatic rings in the structure or is the dibenzofuranyl group, R 3 is a hydrogen atom, a halogen atom, a C 1 -C 4 alkyl group, a C 1 -C 4 alkoxy group, a hydroxyl group, a phenyl group or a benzyl group, R 4 is a hydrogen atom, a halogen atom or a C 1 -C 4 alkyl group, and their addition salts with a non-toxic acid, especially the pharmaceutically acceptable salts. It further relates to the process for their preparation, to the pharmaceutical compositions in which they are present, and to their use as pharmacologically active substances, especially in the case of the treatment of diabetes, diseases due to hyperglycemia, hypertriglyceridemia, dyslipidemia or obesity.

  本发明涉及通式(I)化合物中选自2-硫代海因的化合物：其中，特别是其中一个取代基R1和R2包含两个芳香环结构或为二苯并呋喃基团，R3为氢原子、卤素原子、C1-C4烷基团、C1-C4烷氧基团、羟基团、苯基团或苄基团，R4为氢原子、卤素原子或C1-C4烷基团，以及它们与非毒性酸的加成盐，特别是药学上可接受的盐。本发明还涉及它们的制备方法、含有它们的药物组合物，以及它们作为药理活性物质，特别是在治疗糖尿病、高血糖引起的疾病、高甘油三酯血症、血脂异常或肥胖症中的应用。
• Acid halide and/or acyllactam functional compounds and polylactam block copolymers derived therefrom
  申请人：STAMICARBON B.V.

  公开号：EP0404255A1

  公开（公告）日：1990-12-27

  The invention relates to acid halide and/or acyllactam functional compounds, to polylactam block copolymers derived therefrom by lactam polymerization at a lactam group, and to the use of such block copolymers in polyamide mixtures. The compounds contain liquid crystalline compounds or compounds which combine with acyllactam to form a compound with liquid crystalline properties. The products of this invention are useful as accelerators in the preparation of nylon block copolymers, in particular block copolymers with improved stiffness. The block copolymers are useful in products requiring good tensile strength, chemical resistance and/or heat resistance, and are particularly useful in electrical engineering applications and in the aircraft industry.

  该发明涉及酸卤和/或酰乳酰胺功能化合物，以及由此类化合物通过在乳酰胺基团上进行乳酰聚合而衍生的聚乳酰块共聚物，以及在聚酰胺混合物中使用这种块共聚物。这些化合物含有液晶化合物或与酰乳酰胺结合形成具有液晶性能的化合物。该发明的产品可用作尼龙块共聚物制备中的催化剂，特别是改善了刚度的块共聚物。这些块共聚物适用于需要良好抗拉强度、化学抵抗力和/或耐热性的产品，尤其适用于电气工程应用和航空工业中。
• Methods for making colorant compounds
  申请人：Xerox Corporation.

  公开号：US20040082801A1

  公开（公告）日：2004-04-29

  Disclosed is a process for preparing a colorant of the formula 1 wherein Y is a hydrogen atom or a bromine atom, n is an integer of 0, 1, 2, 3, or 4, R 1 is an alkylene group or an arylalkylene group, R 2 is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, and R 4 is an alkyl group, an aryl group, an arylalkyl group, or an alkylaryl group, can be prepared by a process which comprises (a) preparing a first reaction mixture by admixing (1) leucoquinizarin and, optionally, quinizarin, (2) an aminobenzene substituted with an alcohol group of the formula —R 1 —OH, (3) boric acid, and (4) an optional solvent, and heating the first reaction mixture to prepare an alcohol-substituted colorant of the formula 2 followed by (b) converting the colorant thus prepared to either (i) an ester-substituted colorant by reaction with an esterification compound which is either (A) an anhydride of the formula 3 or (B) an acid of the formula R 2 COOH in the presence of an optional esterification catalyst, or (ii) a urethane-substituted colorant by reaction with an isocyanate compound of the formula R 4 —N═C═O and (c) brominating the colorant thus prepared, wherein either conversion to ester or urethane can be performed before bromination or bromination can be performed before conversion to ester or urethane.

  本发明揭示了一种制备化学式1所示颜料的方法，其中Y为氢原子或溴原子，n为0、1、2、3或4的整数，R1为烷基或芳基烷基，R2为烷基、芳基、芳基烷基或烷基芳基，R4为烷基、芳基、芳基烷基或烷基芳基。该方法包括以下步骤：(a)通过混合(1)白酚喹啉和可选的喹啉，(2)带有醇基的氨基苯的化合物，其化学式为-R1-OH，(3)硼酸和(4)可选的溶剂来制备第一反应混合物，然后加热第一反应混合物以制备化学式2的醇基取代的颜料；(b)将所制备的颜料转化为酯基取代的颜料，方法为与酯化化合物(A)化学式3的酐或(B)化学式R2COOH的酸在可选的酯化催化剂的存在下反应，或与化学式R4-N=C=O的异氰酸酯化合物反应以制备脲基取代的颜料；(c)溴化所制备的颜料，其中酯化或脲化可以在溴化之前进行，也可以在溴化之后进行。
• [EN] [0001] ENERGY EFFICIENT MANUFACTURING PROCESS FOR PREPARING N,0- TRIGLYCIDYL AMINOPHENOLS<br/>[FR] PROCÉDÉ DE FABRICATION ÉCONOME EN ÉNERGIE SERVANT À PRÉPARER DES N,O-TRIGLYCIDYLAMINOPHÉNOLS
  申请人：ADITYA BIRLA CHEMICALS THAILAND LTD

  公开号：WO2015174936A1

  公开（公告）日：2015-11-19

  The invention relates to an improved process for making monomelic triglycidyl compounds, wherein the triglycidyl compounds include N, O-triglycidyl compounds containing at least one primary aromatic amine and one phenolic functional group attached to the same or a different aromatic ring. The methods of the present invention result in the production of N, O-triglycidyl compounds, such as those of formula I and II. The improved process is energy efficient, environment friendly, and results in increased yields of product. The methods of the present invention can be performed in the absence of protic organic co-solvents during the reaction of an epihalohyrdrin with an aminophenol, such as compounds of fonnula III and IV, which provides an intermediate halohydiin compound. The methods of the present invention may also be performed in the absence of a phase transfer catalyst.

  本发明涉及一种改进的单芳香胺和一个酚官能团连接在同一环或不同芳香环上的N，O-三环氧丙基化合物的制备方法。本发明的方法可制备N，O-三环氧丙基化合物，例如公式I和II所示的化合物。改进的方法具有节能环保，产品收率高的特点。本发明的方法可以在无极性有机共溶剂的情况下进行，例如使用公式III和IV所示的氨基酚与环氧卤代烷反应，从而提供中间体卤代环氧化合物。本发明的方法也可以在没有相转移催化剂的情况下进行。