10-[2-(Ethylamino)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid | 114873-39-1

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 10-[2-(Ethylamino)-2-oxoethyl]-1,4,7,10-tetraazacyclododecane-1,4,7-triacetic acid
• 英文别名: 2-[4,7-bis(carboxymethyl)-10-[2-(ethylamino)-2-oxoethyl]-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• CAS: 114873-39-1
• 化学式: C₁₈H₃₃N₅O₇
• 分子量: 431.5
• InChiKey: UGOGOTKEQKMDTK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.2
• 重原子数：
  30
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  154
• 氢给体数：
  4
• 氢受体数：
  11

文献信息

• HBED-bisphosphonates, radiometal conjugates and their use as theranostic agents
  申请人：Five Eleven Pharma Inc.

  公开号：US10253052B2

  公开（公告）日：2019-04-09

  The present invention relates to compounds according to Formula I or Formula II, which are potential bone imaging agents. Certain compounds labeled with 68Ga displayed excellent bone uptake and retention. The present invention also relates to pharmaceutical compositions comprising a pharmaceutical acceptable carrier and a compound of Formula I or Formula II or a pharmaceutically acceptable salt thereof.

  本发明涉及符合式 I 或式 II 的化合物，它们是潜在的骨成像剂。某些用 68Ga 标记的化合物显示出优异的骨吸收和保留能力。本发明还涉及药物组合物，其中包含药物可接受载体和式 I 或式 II 的化合物或其药物可接受盐。
• POLYAZACYCLOALKANES AS DICHELANTS
  申请人：NYCOMED SALUTAR, INC.

  公开号：EP0722442A1

  公开（公告）日：1996-07-24
• UREA-BASED PROSTATE SPECIFIC MEMBRANE ANTIGEN (PSMA) INHIBITORS FOR IMAGING AND THERAPY
  申请人：Five Eleven Pharma Inc.

  公开号：EP3397968B1

  公开（公告）日：2021-09-29
• CONJUGATES OF 19F MR IMAGING TRACERS FOR USE IN MULTI-CHROMIC MRI IMAGING
  申请人：Yu Yihua Bruce

  公开号：US20110217241A1

  公开（公告）日：2011-09-08

  Compositions for producing multi-chromic (“color”) magnetic resonance images (MRI). The compositions for use as MRI imaging agents include a magnetic resonance imaging tracer having a signal emitter, such as a 19 F imaging tracer ( 19 FIT), conjugated with a magnetic signal modulator, such as a paramagnetic functional group or a paramagnetic ion. The 19 FIT and the signal modulator (M) are joined covalently by a chelator such as DOTA, forming a nanometer-sized fluorinated paramagnetic complex 19 FIT-DOTA-M. Other signal emitters, such as 31 P imaging tracer ( 31 PIT), can also be modulated using this strategy (i.e., 31 PIT-DOTA-M) to generate multi-chromic 31 P MRI or MRS.
• Molecular constructs with targeting and effector moieties
  申请人：Immunwork Inc.

  公开号：US20160208021A1

  公开（公告）日：2016-07-21

  The present disclosure provides various molecular constructs having a targeting element and an effector element. Methods for treating various diseases using such molecular constructs are also disclosed.