N,N-Diisobutyl-propionamid | 3007-59-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N,N-Diisobutyl-propionamid
• 英文别名: Diisobutyl-propionamid；N,N-Bis(2-methylpropyl)propanamide
• CAS: 3007-59-8
• 化学式: C₁₁H₂₃NO
• mdl: MFCD06152761
• 分子量: 185.31
• InChiKey: PKCDVUYGEAUYRP-UHFFFAOYSA-N

物化性质

• 沸点：
  234.9±8.0 °C(Predicted)
• 密度：
  0.860±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.9
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.909
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为产物：
  描述：

  二异丁胺 、 (2,4-二硝基苯基)丙酸酯 以 乙腈 为溶剂， 生成 N,N-Diisobutyl-propionamid 、 2,4-二硝基苯酚(1-)
  参考文献：
  名称：

  苯乙酸芳基酯与仲胺在 MeCN 中的反应。乙烯酮形成消除和 E2 和 E1cb 并发机制中的结构 - 反应性关系

  摘要：

  已经对 MeCN 中由 R2NH 促进的芳基乙酸 1 和 2 的芳基酯的消除反应进行了动力学研究。反应是二级反应，表现出 β = 0.44−0.84，|βlg| = 0.41−0.50，ρH = 2.0−3.6。布朗斯台德β和|βlg| β-芳基取代基的吸电子能力降低。Hammett ρH 值几乎保持不变，但 |βlg| 值随着基础强度变弱而增加。随着离去基团从 4-硝基苯氧基变为 2,4-二硝基苯氧基，ρH 和 β 均降低。结果与 E2 机制和具有对应于质子转移的大水平分量的反应坐标一致。当碱-溶剂系统从 R2NH-MeCN 变为 R2NH/R2NH2+-70 mol % MeCN(aq) 时，Bronsted β、ρH 和 |βlg| 减少。最后，

  DOI：

  10.1021/ja961294k

文献信息

• Inhibitors of VEGF receptor and HGF receptor signaling
  申请人：Saavedra Mario Oscar

  公开号：US20070004675A1

  公开（公告）日：2007-01-04

  The invention relates to the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention provides compounds and methods for inhibiting VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions

  该发明涉及抑制VEGF受体信号和HGF受体信号。该发明提供了抑制VEGF受体信号和HGF受体信号的化合物和方法。该发明还提供了治疗细胞增殖性疾病和病况的组合物和方法。
• Inhibitors of protein tyrosine kinase activity
  申请人：Raeppel Stephane

  公开号：US20080004273A1

  公开（公告）日：2008-01-03

  This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  这项发明涉及抑制蛋白酪氨酸激酶活性的化合物。具体而言，该发明涉及抑制生长因子受体蛋白酪氨酸激酶活性的化合物，导致受体信号传导的抑制，例如抑制VEGF受体信号传导和HGF受体信号传导。更具体地，该发明涉及用于抑制VEGF受体信号传导和HGF受体信号传导的化合物、组合物和方法。该发明还提供了用于治疗细胞增殖性疾病和病况的组合物和方法。
• INHIBITORS OF PROTEIN TYROSINE KINASE ACTIVITY
  申请人：Saavedra Mario Oscar

  公开号：US20080064718A1

  公开（公告）日：2008-03-13

  This invention relates to compounds that inhibit protein tyrosine kinase activity. In particular the invention relates to compounds that inhibit the protein tyrosine kinase activity of growth factor receptors, resulting in the inhibition of receptor signaling, for example, the inhibition of VEGF receptor signaling and HGF receptor signaling. More particularly, the invention relates to compounds, compositions and methods for the inhibition of VEGF receptor signaling and HGF receptor signaling. The invention also provides compositions and methods for treating cell proliferative diseases and conditions.

  本发明涉及抑制蛋白酪氨酸激酶活性的化合物。特别是，本发明涉及抑制生长因子受体蛋白酪氨酸激酶活性的化合物，从而抑制受体信号传导，例如抑制VEGF受体信号和HGF受体信号的传导。更具体地，本发明涉及用于抑制VEGF受体信号和HGF受体信号的化合物、组合物和方法。本发明还提供了用于治疗细胞增殖性疾病和病状的组合物和方法。
• METHODS AND COMPOSITIONS FOR USE IN OIL AND/OR GAS WELLS COMPRISING A TERPENE ALCOHOL
  申请人：Flotek Chemistry, LLC

  公开号：EP3144366A1

  公开（公告）日：2017-03-22

  Methods and compositions comprising an emulsion or a microemulsion for use in various aspects of the life cycle of an oil and/or gas well are provided. In some embodiments, the emulsion or the microemulsion comprises an aqueous phase, a nonaqueous phase comprising a terpene alcohol a non-oxygenated terpene, and a surfactant, and optionally, one or more additives.

  本文提供了包含乳液或微乳液的方法和组合物，可用于油井和/或气井生命周期的各个方面。在某些实施方案中，乳液或微乳液包括水相、由萜烯醇、非氧萜烯和表面活性剂组成的非水相及一种或多种添加剂。
• Methods and compositions for use in oil and/or gas wells
  申请人：Flotek Chemistry, LLC

  公开号：US10000693B2

  公开（公告）日：2018-06-19

  Methods and compositions comprising an emulsion or a microemulsion for use in various aspects of the life cycle of an oil and/or gas well are provided. In some embodiments, the emulsion or the microemulsion comprises water, a solvent, and a surfactant, and optionally, one or more additives.

  本文提供了包含乳液或微乳液的方法和组合物，用于油井和/或气井生命周期的各个方面。在某些实施方案中，乳液或微乳液包括水、溶剂和表面活性剂，以及可选的一种或多种添加剂。