1-Triacontanethiol | 66213-99-8

• 分子结构分类: 有机化合物 - 有机硫化合物 - 硫醇
• 英文名称: 1-Triacontanethiol
• 英文别名: triacontane-1-thiol
• CAS: 66213-99-8
• 化学式: C₃₀H₆₂S
• 分子量: 454.9
• InChiKey: UNPYGJMJLZPWAX-UHFFFAOYSA-N

物化性质

• 熔点：
  66.5°C (estimate)
• 沸点：
  491.55°C (rough estimate)
• 密度：
  0.8812 (rough estimate)

计算性质

• 辛醇/水分配系数(LogP)：
  15.9
• 重原子数：
  31
• 可旋转键数：
  28
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  1
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• METHOD FOR LIQUID-PHASE SYNTHESIS OF NUCLEIC ACID
  申请人：Takeda Pharmaceutical Company Limited

  公开号：US20150315229A1

  公开（公告）日：2015-11-05

  In this method, an oligonucleotide is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R 1 , Y, Base, Z, Ar, R 2 , R 3 and n are each as defined in Claim 1 ]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method cars dispense with columm-chromalographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

  在这种方法中，通过使用一种由式(I)所表示的新型核苷单体化合物作为合成单元来制备寡核苷酸。其中，X、R1、Y、Base、Z、Ar、R2、R3和n如权利要求1所定义。该新型核苷单体化合物是一种核苷，其碱基基团被取代了至少一个疏水基团的芳香烃环羰基或硫羰基。该方法不需要在每次反应中进行柱层析纯化，并且不仅可以在3'-方向上进行碱基延伸，还可以在5'-方向上进行碱基延伸，从而实现寡核苷酸的高效液相大规模合成。
• Polymer parts
  申请人：Sony DADC Austria AG

  公开号：EP2792471A1

  公开（公告）日：2014-10-22

  A method of producing a polymer part comprising the following steps: (a) incorporating a hydrophobic small molecule into the polymer before, during or after manufacture of the polymer part, the hydrophobic small molecule and the polymer being essentially inert to one another; and (b) annealing the polymer part to induce migration of the hydrophobic small molecules to a surface of the polymer part to provide that surface with a specified degree of hydrophobicity defined by the combination of the polymer and the hydrophobic small molecule; is described. Polymer parts made according to the method are also described.

  一种生产聚合物部件的方法，包括以下步骤：(a) 在制造聚合物部件之前、期间或之后，将疏水性小分子掺入聚合物中，疏水性小分子和聚合物基本上互为惰性；以及 (b) 对聚合物部件进行退火处理，促使疏水性小分子迁移到聚合物部件的表面，使该表面具有由聚合物和疏水性小分子的组合确定的特定疏水性。还描述了根据该方法制造的聚合物部件。
• Method of producing a polymer part and polymer part
  申请人：STRATEC CONSUMABLES GmbH

  公开号：US10611890B2

  公开（公告）日：2020-04-07

  A method of producing a polymer part comprising the following steps: (a) incorporating a hydrophobic small molecule into the polymer before, during or after manufacture of the polymer part, the hydrophobic small molecule and the polymer being essentially inert to one another; and (b) annealing the polymer part to induce migration of the hydrophobic small molecules to a surface of the polymer part to provide that surface with a specified degree of hydrophobicity defined by the combination of the polymer and the hydrophobic small molecule; is described. Polymer parts made according to the method are also described.

  一种生产聚合物部件的方法，包括以下步骤：(a) 在制造聚合物部件之前、期间或之后，将疏水性小分子掺入聚合物中，疏水性小分子和聚合物基本上互为惰性；以及 (b) 对聚合物部件进行退火处理，促使疏水性小分子迁移到聚合物部件的表面，使该表面具有由聚合物和疏水性小分子的组合确定的特定疏水性。还描述了根据该方法制造的聚合物部件。
• Method for liquid-phase synthesis of nucleic acid
  申请人：TAKEDA PHARMACEUTICAL COMPANY LIMITED

  公开号：US10730904B2

  公开（公告）日：2020-08-04

  In this method, an oligonucleotide represented by formula (II) [wherein Y1, Q, Base, r and r′ are each as defined in claim 1] is prepared by using, as a synthesis unit, a novel nucleoside monomer compound represented by formula (I) [wherein X, R1, Y, Base, Z, Ar, R2, R3 and n are each as defined in claim 1]. The novel nucleoside monomer compound is a nucleoside, the base moiety of which is substituted with an aromatic-hydrocarbon-ring-carbonyl or -thiocarbonyl group having at least one hydrophobic group. The method can dispense with column-chromatographic purification in every reaction, and enables base elongation not only in the 3′-direction but also in the 5′-direction, thus attaining efficient liquid-phase mass synthesis of an oligonucleotide.

  在该方法中，使用式(I)代表的新型核苷单体化合物[其中X、R1、Y、Base、Z、Ar、R2、R3和n各自如权利要求1中定义]作为合成单元，制备式(II)代表的寡核苷酸[其中Y1、Q、Base、r和r′各自如权利要求1中定义]。新型核苷单体化合物是一种核苷，其碱基被具有至少一个疏水基团的芳香-烃环-羰基或-硫代羰基取代。该方法在每个反应中都无需柱色谱纯化，不仅可以在 3′方向上进行碱基延伸，还可以在 5′方向上进行碱基延伸，从而实现寡核苷酸的高效液相大规模合成。
• Polymer slides having hydrophobic small molecules
  申请人：STRATEC Consumables GmbH

  公开号：US10800895B2

  公开（公告）日：2020-10-13

  A plurality of polymer slides, each having a polymer part with a first polymer surface portion uncoated and a second surface portion coated with a metal. The first and second surface portions each have different surface coating properties and have respective first and second specified degrees of hydrophobicity which are different from each other. A hydrophobic small molecule is located in the polymer part of each polymer slide, and the hydrophobic small molecule and the polymer are essentially inert to one another. Adjacent polymer slides are arranged in a manner that the first polymer surface of one slide faces a metal coated second surface portion of another slide. The hydrophobic small molecule evaporates from said first polymer surface portion of the polymer part of one polymer slide onto the adjacent metal coated second surface portion of another polymer slide.

  多个聚合物载玻片，每个载玻片都有一个聚合物部分，第一聚合物表面部分没有涂层，第二表面部分涂有金属。第一和第二表面部分各自具有不同的表面涂层特性，并具有各自不同的第一和第二疏水性。疏水小分子位于每个聚合物载玻片的聚合物部分，疏水小分子和聚合物之间基本上是惰性的。相邻聚合物载玻片的排列方式是，一个载玻片的第一聚合物表面朝向另一个载玻片的第二表面金属涂层部分。疏水小分子从一个聚合物载玻片的聚合物部分的第一聚合物表面蒸发到相邻的另一个聚合物载玻片的涂有金属的第二表面部分上。