N5-2,4-(dichloro)phenyl biguanide hydrochloride | 6634-65-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N5-2,4-(dichloro)phenyl biguanide hydrochloride
• 英文别名: 1-(2,4-Dichlorophenyl)biguanide hydrochloride；1-(diaminomethylidene)-2-(2,4-dichlorophenyl)guanidine;hydrochloride
• CAS: 6634-65-7
• 化学式: C₈H₉Cl₂N₅*ClH
• 分子量: 282.56
• InChiKey: OSGGBIXVZCEAHI-UHFFFAOYSA-N

物化性质

• 熔点：
  259.5-263.5 °C(lit.)

计算性质

• 辛醇/水分配系数(LogP)：
  -3.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  104
• 氢给体数：
  4
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  N5-2,4-(dichloro)phenyl biguanide hydrochloride 在 盐酸 作用下， 生成 1-amidino-3-(2,4-dichlorophenyl)urea
  参考文献：
  名称：

  Douglas; Diamond; Studt, Arzneimittel-Forschung/Drug Research, 1978, vol. 28, # 8 A, p. 1435 - 1441

  摘要：

  DOI：
• 作为产物：
  描述：

  2,4-二氯苯胺 、 二聚氰胺 在 盐酸 作用下， 以 正丁醇 为溶剂， 反应 2.0h， 以54%的产率得到N5-2,4-(dichloro)phenyl biguanide hydrochloride
  参考文献：
  名称：

  BIGUANIDE COMPOUNDS AND USE THEREOF

  摘要：

  本发明涉及双胍类化合物及其使用，更具体地涉及表现出对抑制癌细胞增殖、抑制癌转移和复发具有优异效果的双胍衍生物，以及制备该化合物的方法、含有该化合物作为活性成分的药物组合物，以及包括向需要的受试者施用所述组合物的有效量的步骤的癌症预防或治疗方法。

  公开号：

  US20150126518A1

文献信息

• 바이구아나이드 화합물 및 이의 용도
  申请人：IMMUNOMET THERAPEUTICS INC. 이뮤노메트테라퓨틱스 인코포레이티드(520150627264)

  公开号：KR20210014090A

  公开（公告）日：2021-02-08

  본 발명은 바이구아나이드 화합물 및 이의 용도에 관한 것으로서, 더욱 자세하게는 암세포 증식 억제, 암 전이와 암 재발을 억제에 우수한 효과를 나타내는 바이구아나이드 유도체, 이의 제조 방법 및 이를 유효 성분으로 함유하는 약학 조성물에 관한 것이다.

  This is the translation of the text you provided: This invention relates to biguanide compounds and their uses, more specifically to biguanide derivatives that exhibit excellent effects in inhibiting cancer cell proliferation, cancer metastasis, and cancer recurrence, as well as to a method for producing them and pharmaceutical compositions containing them as active ingredients.
• SEMI-PERMANENT HAIR STRAIGHTENING COMPOSITION AND METHOD
  申请人：Lubrizol Advanced Materials, Inc.

  公开号：EP3065831A1

  公开（公告）日：2016-09-14
• Semi-Permanent Hair Straightening Composition And Method
  申请人：LUBRIZOL ADVANCED MATERIALS, INC.

  公开号：US20160296449A1

  公开（公告）日：2016-10-13

  A composition and a process for straightening hair are disclosed. The process includes coating keratin fibers with a composition comprising a thermally-activated agent and a guanidine moiety containing adjuvant compound and contacting the coated keratin fibers with a heating device at a temperature of at least 185 C for sufficient time to modify the keratin fibers.
• [EN] SEMI-PERMANENT HAIR STRAIGHTENING COMPOSITION AND METHOD<br/>[FR] COMPOSITION ET PROCÉDÉ DE DÉFRISAGE SEMI-PERMANENT DES CHEVEUX
  申请人：LUBRIZOL ADVANCED MAT INC

  公开号：WO2015069823A1

  公开（公告）日：2015-05-14

  A composition and a process for straightening hair are disclosed. The process includes coating keratin fibers with a composition comprising a thermally-activated agent and a guanidine moiety containing adjuvant compound and contacting the coated keratin fibers with a heating device at a temperature of at least 185C for sufficient time to modify the keratin fibers.
• BIGUANIDE COMPOUNDS AND USE THEREOF
  申请人：HANALL BIOPHARMA CO., LTD.

  公开号：US20150126518A1

  公开（公告）日：2015-05-07

  The present invention relates to biguanide compounds and use thereof, more particularly, to biguanide derivatives exhibiting excellent effects for inhibition of cancer cell proliferation and inhibition of cancer metastasis and recurrence, a method for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and a method of prevention or treatment of cancer comprising the step of administering an effective amount of the composition to a subject in need thereof.

  本发明涉及双胍类化合物及其使用，更具体地涉及表现出对抑制癌细胞增殖、抑制癌转移和复发具有优异效果的双胍衍生物，以及制备该化合物的方法、含有该化合物作为活性成分的药物组合物，以及包括向需要的受试者施用所述组合物的有效量的步骤的癌症预防或治疗方法。