sec-Butyl itaconate | 56525-13-4

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: sec-Butyl itaconate
• 英文别名: 3-butan-2-yloxycarbonylbut-3-enoic acid
• CAS: 56525-13-4
• 化学式: C₉H₁₄O₄
• 分子量: 186.2
• InChiKey: SKQYQZAJMXQLCP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  63.6
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Constrained compounds as CGRP-receptor antagonists
  申请人：Chaturvedula V. Prasad

  公开号：US20060094707A1

  公开（公告）日：2006-05-04

  The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

  这项发明涵盖了受限的双环和三环CGRP受体拮抗剂，用于识别它们的方法，包含它们的药物组合物，以及它们在治疗偏头痛和其他头痛、神经源性血管舒张、神经源性炎症、热损伤、循环性休克、与绝经期相关的潮红、气道炎症性疾病（如哮喘和慢性阻塞性肺病（COPD））以及其他可以通过CGRP受体拮抗来治疗的疾病的治疗方法。
• CONSTRAINED COMPOUNDS AS CGRP-RECEPTOR ANTAGONISTS
  申请人：Chaturvedula Prasad V.

  公开号：US20070259851A1

  公开（公告）日：2007-11-08

  The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

  本发明包括受约束的双环和三环CGRP受体拮抗剂，识别它们的方法，包含它们的药物组合物，以及它们在治疗偏头痛和其他头痛、神经源性血管扩张、神经性炎症、热损伤、循环性休克、与更年期相关的潮红、气道炎症性疾病（如哮喘和慢性阻塞性肺病（COPD））中的用途，以及其他可以通过CGRP受体拮抗剂治疗的疾病。
• Inhibitors of phophodiesterase type-IV
  申请人：Palle P. Venkata

  公开号：US20050075383A1

  公开（公告）日：2005-04-07

  The present invention relates to isoxazoline derivatives, which can be used as selective inhibitors of phosphodiesterase (PDE) type IV. In particular, compounds disclosed herein can be useful in the treatment of AIDS, asthma, arthritis, bronchitis, chronic obstructive pulmonary disease (COPD), psoriasis, allergic rhinitis, shock, atopic dermatitis, Crohn's disease, adult respiratory distress syndrome (ARDS), eosinophilic granuloma, allergic conjunctivitis, osteoarthritis, ulcerative colitis and other inflammatory diseases in a patient, particularly in humans. The present invention also relates to processes for the preparation of disclosed compounds, as well as pharmaceutical compositions thereof, and their use as phosphodiesterase (PDE) type IV inhibitors.

  本发明涉及异噁唑啉衍生物，可用作选择性磷酸二酯酶（PDE）IV型抑制剂。特别是，所披露的化合物可用于治疗艾滋病、哮喘、关节炎、支气管炎、慢性阻塞性肺疾病（COPD）、银屑病、过敏性鼻炎、休克、特应性皮炎、克隆病、成人呼吸窘迫综合症（ARDS）、嗜酸性肉芽肿、过敏性结膜炎、骨关节炎、溃疡性结肠炎和其他炎症性疾病的患者，特别是人类。本发明还涉及所披露化合物的制备方法，以及其作为磷酸二酯酶（PDE）IV型抑制剂的药物组合物和用途。
• Constrained Compounds as CGRP-Receptor Antagonists
  申请人：Chaturvedula Prasad V.

  公开号：US20080287422A1

  公开（公告）日：2008-11-20

  The invention encompasses constrained bicyclic and tricyclic CGRP-receptor antagonists, methods for identifying them, pharmaceutical compositions comprising them, and methods for their use in therapy for treatment of migraine and other headaches, neurogenic vasodilation, neurogenic inflammation, thermal injury, circulatory shock, flushing associated with menopause, airway inflammatory diseases, such as asthma and chronic obstructive pulmonary disease (COPD), and other conditions the treatment of which can be effected by the antagonism of CGRP-receptors.

  该发明涵盖了受限的双环和三环CGRP受体拮抗剂，其识别方法，包含它们的药物组合物，以及将其用于治疗偏头痛和其他头痛，神经源性血管扩张，神经源性炎症，热伤害，循环性休克，与更年期有关的潮红，气道炎症性疾病（如哮喘和慢性阻塞性肺疾病（COPD））以及其他通过抗CGRP受体作用进行治疗的疾病的治疗方法。
• POLYMERS AND USES THEREOF
  申请人：REVOLYMER (U.K.) LIMITED

  公开号：US20160250134A1

  公开（公告）日：2016-09-01

  Uses of polymers including monomeric units based on salts of itaconic acid as film formers are disclosed. The polymers confer good film-forming characteristics to the compositions to which they are added, making them suitable for use in cosmetic and personal care product, in particular those that are applied to the skin, hair or nails. The polymers offer a variety of benefits to the products into which they are incorporated, increasing their performance, longevity or adhesion to the human body and improving their feel or appearance during use. Also disclosed are methods of preparing the polymers and the cosmetic and personal care compositions.

  本文揭示了以丙烯酸盐为基础的单体单元的聚合物在成膜剂中的应用。这些聚合物为加入它们的组合物提供了良好的成膜特性，使它们适用于化妆品和个人护理产品，特别是那些用于皮肤、头发或指甲的产品。这些聚合物为它们被纳入的产品提供了各种好处，增加了它们的性能、寿命或与人体的附着力，并在使用过程中改善了它们的手感或外观。本文还揭示了制备这些聚合物和化妆品和个人护理组合物的方法。