(4,5-dimethyl-1(3)H-benzoimidazol-2-yl)-guanidine | 41926-61-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: (4,5-dimethyl-1(3)H-benzoimidazol-2-yl)-guanidine
• 英文别名: 4,5-dimethyl-2-guanidinobenzimidazole；4,5-Dimethyl-2-guanidinobenzimidazol；2-(4,5-dimethyl-1H-benzimidazol-2-yl)guanidine
• CAS: 41926-61-8
• 化学式: C₁₀H₁₃N₅
• 分子量: 203.247
• InChiKey: HHNZIWONPYANMZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  15
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  93.1
• 氢给体数：
  3
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  3,4-二甲基-O-苯二胺 、 二聚氰胺 以 盐酸 为溶剂， 以38%的产率得到(4,5-dimethyl-1(3)H-benzoimidazol-2-yl)-guanidine
  参考文献：
  名称：

  Anti-hypertensive compositions of benzimidazole derivatives

  摘要：

  抗高血压药物组合物包括式（II）的化合物##SPC1##或其药学上可接受的盐或溶剂，其中R.sub.1是腈或酰胺基；R.sub.2是氢或低碳氢化物；R.sub.3、R.sub.4、R.sub.5和R.sub.6可以相同也可以不同，分别选自氢、卤素、硝基、三氟甲基、低烷基、低酰基、羟基、低醚化羟基或低酰化羟基；以及药学上可接受的载体。式（II）的化合物也可用作合成相应的2-氨基咪唑啉化合物的中间体。

  公开号：

  US03935314A1

文献信息

• NEW BENZIMIDAZOLE COMPOUNDS FOR USE AS ACTIVE THERAPEUTIC SUBSTANCES, PROCESS FOR THE PREPARATION OF THESE COMPOUDNS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM
  申请人：Pharmacia AB

  公开号：EP1155014A1

  公开（公告）日：2001-11-21
• US3935314A
  申请人：——

  公开号：US3935314A

  公开（公告）日：1976-01-27
• US6329383B1
  申请人：——

  公开号：US6329383B1

  公开（公告）日：2001-12-11
• [EN] NEW BENZIMIDAZOLE COMPOUNDS FOR USE AS ACTIVE THERAPEUTIC SUBSTANCES, PROCESS FOR THE PREPARATION OF THESE COMPOUDNS AND PHARMACEUTICAL COMPOSITIONS COMPRISING THEM<br/>[FR] NOUVEAUX COMPOSES DE BENZIMIDAZOLE POUVANT ETRE UTILISES COMME PRINCIPES ACTIFS THERAPEUTIQUES, PROCEDE PERMETTANT DE LES PREPARER ET COMPOSITIONS PHARMACEUTIQUES LES CONTENANT
  申请人：PHARMACIA & UPJOHN AB

  公开号：WO2000043387A1

  公开（公告）日：2000-07-27

  The present invention relates to new benzimidazole compounds with general structure (I): in which Y-X is ⊃C = X when X is NR8, O, or S and R2 is H, alkyl, substituted alkylaryl or substituted aryl; or Y-X is ⊃C-X when X is H, alkyl, substituted alkyl, aryl, substituted aryl, OR9 or NHR9 and R2 is a bond to Y; Z = O, S or NR12; R1 is H, alkyl, substituted alkyl, aryl or substituted aryl; R3 is H, alkyl, substituted alkyl, aryl or substituted aryl, OR9 or NHR9; R4, R5, R6, R7 are H, halogen, OR10, NR10, R11, NO2, CF3, CN, COR8, COOR8, CONHR8 and/or N3 in any combination and/or two adjacent R4, R5, R6 or R7 form a carbocyclic or heterocyclic ring; R8, R9, R10, R11, R12 and R13 are H, alkyl, substituted alkylaryl, aryl and/or substituted aryl in any combination. These compounds are useful as a human Growth Hormone (hGH) mimetic, which trigger GH agonist effects in animals and especially as an orally availabel human Growth Hormone (hGH).
• Anti-hypertensive compositions of benzimidazole derivatives
  申请人：Beecham Group Limited

  公开号：US03935314A1

  公开（公告）日：1976-01-27

  Antihypertensive pharmaceutical compositions comprising a compound of the formula (II) ##SPC1## or pharmaceutically acceptable salts or solvates thereof wherein R.sub.1 is nitrile or amidino; R.sub.2 is hydrogen or lower hydrocarbon; R.sub.3, R.sub.4, R.sub.5 and R.sub.6 which may be the same or different, are each selected from hydrogen, halogen, nitro, trifluoromethyl, lower alkyl, lower acyl, hydroxyl, lower etherified hydroxyl or lower acylated hydroxyl; together with a pharmaceutically acceptable carrier. The compounds of formula (II) are also useful as intermediates in the synthesis of the corresponding 2-aminoimidazoline compounds.

  抗高血压药物组合物包括式（II）的化合物##SPC1##或其药学上可接受的盐或溶剂，其中R.sub.1是腈或酰胺基；R.sub.2是氢或低碳氢化物；R.sub.3、R.sub.4、R.sub.5和R.sub.6可以相同也可以不同，分别选自氢、卤素、硝基、三氟甲基、低烷基、低酰基、羟基、低醚化羟基或低酰化羟基；以及药学上可接受的载体。式（II）的化合物也可用作合成相应的2-氨基咪唑啉化合物的中间体。