2-(3-carboxybenzoyl)benzoic Acid | 4091-00-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-(3-carboxybenzoyl)benzoic Acid
• CAS: 4091-00-3
• 化学式: C₁₅H₁₀O₅
• 分子量: 270.241
• InChiKey: YPKDHKFXEJNBFR-UHFFFAOYSA-N

物化性质

• 沸点：
  570.9±35.0 °C(Predicted)
• 密度：
  1.403±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  20
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  91.7
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  2-(3-carboxybenzoyl)benzoic Acid 在 sodium hydroxide 、 硫酸 、 potassium carbonate 、 一水合肼 作用下， 以 乙醇 、 N,N-二甲基甲酰胺 为溶剂， 反应 44.0h， 生成 3-[3-(2-Imidazol-1-ylethyl)-4-oxophthalazin-1-yl]benzoic acid
  参考文献：
  名称：

  Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones

  摘要：

  A number of 4-substituted 2-[omega-(1-imidazolyl)allryl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane Az synthetase inhibitory and bronchodilatory activities. The pharmacological evaluation of these compounds disclosed that they have both activities to various extents. Both activities were slightly dependent on the length of the 2-substituents and largely affected by the nature of the 4-substituents. Compounds bearing phenyl and thienyl groups exhibited relatively high and well-rounded activities. Among these compounds, 12j and 15f were found to be the most effective agents having well-rounded activities in vitro and in vivo. Introduction of a carboxyl group reduced both activities contrary to our expectation. 4-(3-Pyridyl)phthalazinone 18b was of particular interest because of unexpectedly high in vivo activities in spite of an absence of significant in vitro activities.

  DOI：

  10.1021/jm00077a008
• 作为产物：
  描述：

  2,3'-Dimethyl-benzophenon 在 吡啶 、 potassium permanganate 作用下， 以 水 为溶剂， 反应 2.0h， 以83%的产率得到2-(3-carboxybenzoyl)benzoic Acid
  参考文献：
  名称：

  Novel antiasthmatic agents with dual activities of thromboxane A2 synthetase inhibition and bronchodilation. 1. 2-[2-(1-Imidazolyl)alkyl]-1(2H)-phthalazinones

  摘要：

  A number of 4-substituted 2-[omega-(1-imidazolyl)allryl]-1(2H)-phthalazinones were synthesized in order to develop agents possessing both thromboxane Az synthetase inhibitory and bronchodilatory activities. The pharmacological evaluation of these compounds disclosed that they have both activities to various extents. Both activities were slightly dependent on the length of the 2-substituents and largely affected by the nature of the 4-substituents. Compounds bearing phenyl and thienyl groups exhibited relatively high and well-rounded activities. Among these compounds, 12j and 15f were found to be the most effective agents having well-rounded activities in vitro and in vivo. Introduction of a carboxyl group reduced both activities contrary to our expectation. 4-(3-Pyridyl)phthalazinone 18b was of particular interest because of unexpectedly high in vivo activities in spite of an absence of significant in vitro activities.

  DOI：

  10.1021/jm00077a008

文献信息

• Optical resins and applications thereof
  申请人：Hitachi Chemical Co., Ltd.

  公开号：US20040152862A1

  公开（公告）日：2004-08-05

  The present invention relates to an optical resin comprising a poly(benzoazole) having repeating units represented by the following general formula (1) as a constituent; and an optical waveguide, an optical filter and an optical lens prepared using the optical resin: 1 wherein R 1 represents a tetravalent organic group having an aromatic ring, N and X in each of the two sets thereof are linked to two atoms at the ortho-position on the aromatic ring of R 1 to form a 5-membered ring, R 2 represents a divalent organic group and X represents an oxygen atom or a sulfur atom. The optical resin of the present invention has high transparency to light rays falling within the near infrared region, shows only small changes in the refractive index and the rate of birefringence as a function of wavelengths of light rays used for the measurement and falling within the near infrared region, has a low rate of birefringence and has high heat-resistance. Therefore, the optical resin of the present invention is suitably used as a resin for preparing optical parts, which are employed for the light rays falling within the wavelength range used in the optical communication.

  本发明涉及一种光学树脂，其成分包括具有下式（1）所代表重复单元的聚苯并唑；以及使用该光学树脂制备的光波导、光学滤波器和光学透镜： 1 其中 R 1 代表具有芳香环的四价有机基团，两组有机基团中的 N 和 X 分别与 R 1 芳香环上正交位置的两个原子相连 1 形成一个五元环，R 2 代表二价有机基团，X 代表氧原子或硫原子。 本发明的光学树脂对近红外区域内的光线具有较高的透明度，折射率和双折射率随用于测量的近红外区域内的光线波长的变化很小，双折射率较低，并且具有较高的耐热性。因此，本发明的光学树脂适合用作制备光学部件的树脂，这些光学部件用于测量光通信所用波长范围内的光线。
• CARBOXYLGRUPPEN TRAGENDE BENZOPHENON- ODER BENZOESÄUREANILID-DERIVATE ALS ENZYMSTABILISATOREN
  申请人：Henkel AG & Co. KGaA

  公开号：EP2115111A1

  公开（公告）日：2009-11-11
• Benzophenone or Benzoic Acid Anilide Derivatives containing Carboxyl Groups as Enzyme Stabilizers
  申请人：Michels Andreas

  公开号：US20100062964A1

  公开（公告）日：2010-03-11

  Washing and cleaning agents containing benzophenone or benzole anilide derivatives containing carboxyl groups, which function as protease inhibitors and are suitable as enzyme stabilizers. Additional subjects are the use of such compounds as reversible inhibitors of a protease and consequently for a washing or cleaning agent formulation, and additional methods and uses relating thereto.
• US7968508B2
  申请人：——

  公开号：US7968508B2

  公开（公告）日：2011-06-28
• [DE] BISACYLGUANIDINE<br/>[EN] BISACYLGUANIDINE<br/>[FR] BISACYLGUANIDINE
  申请人：MERCK PATENT GMBH

  公开号：WO2001087829A1

  公开（公告）日：2001-11-22

  Bisacylguanidine der Formel (I), worin einer der Reste R?1, R2, R3, R4 oder R5¿ und einer der Reste R?6, R7, R8, R9 oder R10¿ (Ia) ist, sowie deren physiologisch unbedenkliche Salze und/oder Solvate, zeigen kardioprotektive Eigenschaften und wirken als Inhibitoren des zellulären Na+/H+-Antiporters vom Subtyp 1.