10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione | 1455342-55-8

• 分子结构分类: 有机化合物 - 苯丙烷和聚酮 - 二芳基庚烷
• 英文名称: 10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione
• 英文别名: 4,10-diphenylindeno[1,2-f]isoindole-1,3,9(2H)-trione；4,10-Diphenylindeno[1,2-f]isoindole-1,3,9-trione；4,10-diphenylindeno[1,2-f]isoindole-1,3,9-trione
• CAS: 1455342-55-8
• 化学式: C₂₇H₁₅NO₃
• 分子量: 401.421
• InChiKey: PWFFMWSIHCPLAV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.1
• 重原子数：
  31
• 可旋转键数：
  2
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  63.2
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione 在 potassium carbonate 、 potassium iodide 作用下， 以 乙腈 为溶剂， 反应 44.0h， 生成 2-{4-[4-(2-fluorophenyl)piperazin-1-yl]butyl}-4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione
  参考文献：
  名称：

  Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives

  摘要：

  A series of arylpiperazine derivatives of 1,16-diphenyl-19-azahexacyclo-[14.5.1.0(2,15).0(3,8).0(9,14).0(17,21)]docosa-2,3,5,7,8,9,11,13,14-nonaene-18,20,22-trione and 4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione was synthesized. The pharmacological profile of compound 4 at the 5-HT1A receptor was measured by binding assay. The title compounds were tested in cell-based assay against the human immunodeficiency virus type-1. The X-ray crystallographic studies of derivatives 2, 6, 7, 11, 19, and 20 were presented.

  DOI：

  10.1007/s00044-013-0740-z
• 作为产物：
  描述：

  水合茚三酮 在 potassium hydroxide 作用下， 以 甲醇 、 乙醇 、 苯 为溶剂， 反应 9.0h， 生成 10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione
  参考文献：
  名称：

  “茚满环”与马来酰亚胺发生狄尔斯-阿尔德反应的意外产物

  摘要：

  摘要 一种通常被称为“茚满环”的杂环化合物与马来酰亚胺发生意想不到的狄尔斯-阿尔德加成反应。所得产物已被分离和表征，以便获得有关其结构和可能的反应机理的信息。3-(2,8-dioxo-1,3-diphenyl-2,8-dihydrocyclopenta[a]inden-8a(1H)-yl)pyrrolidine-2,5-dione 的单晶性质的广泛比较也进行了反应。

  DOI：

  10.1016/j.molstruc.2016.10.067

文献信息

• Synthesis and structure evaluation of new complex butylarylpiperazin-1-yl derivatives
  作者：Daniel Szulczyk、Anna Bielenica、Michał A. Dobrowolski、Łukasz Dobrzycki、Mariola Krawiecka、Bożena Kuran、Marta Struga

  DOI：10.1007/s00044-013-0740-z

  日期：2014.3

  A series of arylpiperazine derivatives of 1,16-diphenyl-19-azahexacyclo-[14.5.1.0(2,15).0(3,8).0(9,14).0(17,21)]docosa-2,3,5,7,8,9,11,13,14-nonaene-18,20,22-trione and 4,10-diphenyl-1H,2H,3H,5H-indeno[1,2-f]isoindole-1,3,5-trione was synthesized. The pharmacological profile of compound 4 at the 5-HT1A receptor was measured by binding assay. The title compounds were tested in cell-based assay against the human immunodeficiency virus type-1. The X-ray crystallographic studies of derivatives 2, 6, 7, 11, 19, and 20 were presented.
• The unexpected product of Diels-Alder reaction between “indanocyclon” and maleimide
  作者：Michał A. Dobrowolski、Piotr Roszkowski、Marta Struga、Daniel Szulczyk

  DOI：10.1016/j.molstruc.2016.10.067

  日期：2017.2

  Abstract A heterocyclic compound commonly known as “indanocyclon” undergoes an unexpected Diels-Alder addition with maleimide. The resulting product has been isolated and characterized in order to get an information about its structure and possible mechanism of the reaction. Extensive comparison of single crystal properties of 3-(2,8-dioxo-1,3-diphenyl-2,8-dihydrocyclopenta[a]inden-8a(1H)-yl)pyrrolidine-2

  摘要 一种通常被称为“茚满环”的杂环化合物与马来酰亚胺发生意想不到的狄尔斯-阿尔德加成反应。所得产物已被分离和表征，以便获得有关其结构和可能的反应机理的信息。3-(2,8-dioxo-1,3-diphenyl-2,8-dihydrocyclopenta[a]inden-8a(1H)-yl)pyrrolidine-2,5-dione 的单晶性质的广泛比较也进行了反应。