5-Amino-5-oxo-2-[(2-phenylacetyl)amino]pentanoic acid;2-phenylacetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-Amino-5-oxo-2-[(2-phenylacetyl)amino]pentanoic acid;2-phenylacetic acid
• 化学式: C21H24N2O6
• 分子量: 400.4
• InChiKey: RUKFOASKJPYUMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.38
• 重原子数：
  29
• 可旋转键数：
  9
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  147
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• PHENYLACETIC ACID COMPOSITIONS FOR TREATING OR PREVENTING ATHEROSCLEROSIS AND RESTENOSIS
  申请人：Burzynski, Stanislaw R.

  公开号：EP1171110B1

  公开（公告）日：2004-04-07
• US6127419A
  申请人：——

  公开号：US6127419A

  公开（公告）日：2000-10-03
• [EN] PHENYLACETIC ACID COMPOSITIONS FOR TREATING OR PREVENTING ATHEROSCLEROSIS AND RESTENOSIS<br/>[FR] COMPOSITIONS D'ACIDE PHENYLACETIQUE POUR LE TRAITEMENT OU LA PREVENTION DE L'ATHEROSCLEROSE ET DE LA RESTENOSE
  申请人：BURZYNSKI STANISLAW R

  公开号：WO2000030627A2

  公开（公告）日：2000-06-02

  Pharmaceutical compositions effective in treating or preventing atherosclerosis and restenosis are disclosed. The pharmaceutical compositions of the present invention comprise one or more compounds selected from the group consisting of phenylacetic acid, pharmaceutically-acceptable salts thereof, pharmaceutically-acceptable precursors thereof, and pharmaceutically-acceptable analogs thereof (e.g., phenylacetylglutamine and iso-phenylacetylglutamine), suitably combined with appropriate carriers, diluents, or excipients. The compositions also optionally contain isoglutamine. Also disclosed are methods for treating or preventing atherosclerosis and restenosis by the administration of pharmaceutical compositions of the present invention.