1,4-Bis(fluoromethanesulfonyloxy)-butane

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: 1,4-Bis(fluoromethanesulfonyloxy)-butane
• 英文别名: 4-(fluoromethylsulfonyloxy)butyl fluoromethanesulfonate
• 化学式: C₆H₁₂F₂O₆S₂
• 分子量: 282.286
• InChiKey: ISIGLRLLIAZYJG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  9
• 环数：
  0.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  104
• 氢给体数：
  0
• 氢受体数：
  8

反应信息

• 作为产物：
  描述：

  1,4-二碘代丁烷 、 Ag-fluoromethanesulfonate 以 乙腈 为溶剂， 反应 7.0h， 以23%的产率得到1,4-Bis(fluoromethanesulfonyloxy)-butane
  参考文献：
  名称：

  The Synthesis of Fluorinated Busulfan and Piposulfan Analogs, Including an Unsymmetrical Bis-sulfonate.

  摘要：

  1,4-Bis(fluoromethylsulfonyloxy)butane, 1,4-bis[3-(fluoromethylsulfonyloxy)-propanoyl] piperazine and 1 -(fluoromethylsulfonyloxy)-4-(methylsulfonyloxy)-butane have been prepared as potential cytostatics of the busulfan type. The rate of hydrolysis of the first-mentioned has been measured.

  DOI：

  10.3891/acta.chem.scand.52-0042

文献信息

• The Synthesis of Fluorinated Busulfan and Piposulfan Analogs, Including an Unsymmetrical Bis-sulfonate.
  作者：Ulla Lange、Alexander Senning、Xiaoxin Qiao、Robert A. Pascal, Jr.、Allen J. Bard、George W. Francis、József Szúnyog、Bengt Långström

  DOI：10.3891/acta.chem.scand.52-0042

  日期：——

  1,4-Bis(fluoromethylsulfonyloxy)butane, 1,4-bis[3-(fluoromethylsulfonyloxy)-propanoyl] piperazine and 1 -(fluoromethylsulfonyloxy)-4-(methylsulfonyloxy)-butane have been prepared as potential cytostatics of the busulfan type. The rate of hydrolysis of the first-mentioned has been measured.