D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-ThrNH2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: D-Nal-Cys-Tyr-D-Trp-Lys-Val-Cys-ThrNH2
• 英文别名: 6-amino-N-[1-[[1-[(1-amino-3-hydroxy-1-oxobutan-2-yl)amino]-1-oxo-3-sulfanylpropan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]-2-[[2-[[2-[[2-[(2-amino-3-naphthalen-2-ylpropanoyl)amino]-3-sulfanylpropanoyl]amino]-3-(4-hydroxyphenyl)propanoyl]amino]-3-(1H-indol-3-yl)propanoyl]amino]hexanamide
• 化学式: C₅₄H₇₁N₁₁O₁₀S₂
• 分子量: 1098.3
• InChiKey: UGVPPRZHXAMSJP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.6
• 重原子数：
  77
• 可旋转键数：
  29
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.41
• 拓扑面积：
  357
• 氢给体数：
  15
• 氢受体数：
  14

文献信息

• PROCESS FOR THE PREPARATION OF PHARMACEUTICAL COMPOSITIONS FOR THE SUSTAINED RELEASE OF SOMATOSTATIN ANALOGS
  申请人：Montes Martin

  公开号：US20130079282A1

  公开（公告）日：2013-03-28

  The invention relates to a process for the preparation of injectable pharmaceutical compositions for the sustained release of somatostatin analogues and to pharmaceutical compositions prepared according to the process. In a preferred aspect the process comprises the steps of combining lanreotide acetate and acetic acid, lyophilizing the resulting mixture only once, and hydrating the lyophilizate. Acetic acid may be added to a desired pH during the final step of the process.
• US9352012B2
  申请人：——

  公开号：US9352012B2

  公开（公告）日：2016-05-31