[(E)-4-hydroxy-4-(2-methylphenyl)but-2-enyl] propanoate | 1210066-98-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: [(E)-4-hydroxy-4-(2-methylphenyl)but-2-enyl] propanoate
• CAS: 1210066-98-0
• 化学式: C₁₄H₁₈O₃
• 分子量: 234.295
• InChiKey: JEKDANSNXUKDQF-RMKNXTFCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  17
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  46.5
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  1-(2-methylphenyl)but-3-en-1-ol 、 丙酸 在 lithium hydroxide monohydrate 、 palladium diacetate 、 丙酸 、 对苯醌 作用下， 反应 24.42h， 以9%的产率得到[(E)-4-hydroxy-4-(2-methylphenyl)but-2-enyl] propanoate
  参考文献：
  名称：

  Palladium-Catalyzed Allylic Acyloxylation of Terminal Alkenes in the Presence of a Base

  摘要：

  The efficiency and the selectivity of the Pd-catalyzed oxidation, in carboxylic acids, of terminal alkenes are strongly improved ill the presence of a base. The methodology IS particularly Well adapted for the oxidation homoallylic alcohols, for which the resulting acyloxylated products are obtained selectively as E-isomers in fair to good yields.

  DOI：

  10.1021/jo902587u

文献信息

• Palladium-Catalyzed Allylic Acyloxylation of Terminal Alkenes in the Presence of a Base
  作者：Emilie Thiery、Chahinez Aouf、Julien Belloy、Dominique Harakat、Jean Le Bras、Jacques Muzart

  DOI：10.1021/jo902587u

  日期：2010.3.5

  The efficiency and the selectivity of the Pd-catalyzed oxidation, in carboxylic acids, of terminal alkenes are strongly improved ill the presence of a base. The methodology IS particularly Well adapted for the oxidation homoallylic alcohols, for which the resulting acyloxylated products are obtained selectively as E-isomers in fair to good yields.