(E)-N'-(4-Phenylbutan-2-ylidene)benzohydrazide | 372960-21-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: (E)-N'-(4-Phenylbutan-2-ylidene)benzohydrazide
• 英文别名: N-[(E)-4-phenylbutan-2-ylideneamino]benzamide
• CAS: 372960-21-9
• 化学式: C₁₇H₁₈N₂O
• 分子量: 266.343
• InChiKey: QHCKGIHINHFNMR-NBVRZTHBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  20
• 可旋转键数：
  5
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  41.5
• 氢给体数：
  1
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  丙烯基三氯硅烷 、 (E)-N'-(4-Phenylbutan-2-ylidene)benzohydrazide 以 N,N-二甲基甲酰胺 为溶剂， 反应 0.3h， 以81%的产率得到N'-(1-methyl-1-phenylethyl-3-butenyl)benzohydrazide
  参考文献：
  名称：

  基于烯丙基三氯硅烷加成苯甲酰腙的高立体选择性合成均烯丙基胺

  摘要：

  烯丙基三氯硅烷在 DMF 中与苯甲酰腙反应，无需使用任何催化剂，以良好到高产率提供相应的高烯丙基苯甲酰肼。在温和的条件下，反应在 0 摄氏度至室温下进行。此外，还发现反应能很好地耐受腙和烯丙基三氯硅烷的空间位阻。事实上，酮衍生的苯甲酰腙与烯丙基三氯硅烷顺利反应，以高产率提供相应的 N'-叔烷基-N-苯甲酰肼。在与 (E)- 和 (Z)-巴豆基三氯硅烷的巴豆化中，分别立体定向地获得了顺式和反加合物。这些反应最有可能通过 R 基团占据轴向位置的环状椅子状过渡态进行。当使用α-杂原子取代的手性苯甲酰腙时，观察到高抗非对映选择性。这些加合物可以很容易地以高产率转化为同型烯丙基胺，无需差向异构化。

  DOI：

  10.1021/ja011125m
• 作为产物：
  描述：

  苄基丙酮 、 苯甲酰肼 在 溶剂黄146 作用下， 以 甲醇 、 正己烷 为溶剂， 反应 12.0h， 生成 (E)-N'-(4-Phenylbutan-2-ylidene)benzohydrazide
  参考文献：
  名称：

  酮衍生的苯甲酰腙的对映选择性烯丙基化：叔卡宾胺的实际合成

  摘要：

  已经开发了一种用于酮衍生的苯甲酰腙的对映选择性烯丙基化的非常实用的方法。先前报道的应变硅环试剂 1 与多种苯甲酰腙反应，得到具有良好至优异对映选择性 (84-97% ee) 的酰肼产物。已经建立了酰基腙与硅烷共价连接的机制。

  DOI：

  10.1021/ja0486418

文献信息

• Cyanation ofN-Acylhydrazones with Trimethylsilyl Cyanide Promoted by a Brønsted Base and a Lewis Acid
  作者：Hideyuki Konishi、Chikako Ogawa、Masaharu Sugiura、Shū Kobayashi

  DOI：10.1002/adsc.200505272

  日期：2005.12

  Cyanation of N-acylhydrazones using trimethylsilyl cyanide (TMSCN) proceeded well in the presence of an amine to afford the corresponding α-hydrazinonitriles in high yields. For less reactive substrates, the combined use of an amine and a catalytic amount of scandium triflate [Sc(OTf)3] was effective to promote the reactions. The mechanistic study suggested that the amine worked as a Brønsted base

  的氰化Ñ -acylhydrazones使用胺，得到相应的α-hydrazinonitriles高产率的存在下进行以及三甲基硅烷基氰化物（TMSCN）。对于反应性较低的底物，胺和催化量的三氟甲磺酸[[Sc（OTf）3 ]的组合使用可有效促进反应。机理研究表明，胺作为布朗斯台德碱起作用。
• Microrna modulators and method for identifying and using the same
  申请人：Huang Qihong

  公开号：US20100196357A1

  公开（公告）日：2010-08-05

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying And Using The Same
  申请人：Huang Qihong

  公开号：US20120010177A1

  公开（公告）日：2012-01-12

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• MicroRNA Modulators and Method for Identifying and Using the Same
  申请人：Huang Qihong

  公开号：US20130023498A1

  公开（公告）日：2013-01-24

  The present invention is a method for identifying agents which modulate microRNA activity. The invention involves contacting a cell harboring a microRNA and a microRNA binding sequence, which is operably linked to a nucleic acid molecule encoding a reporter protein, with a test agent and determining whether the test agent increases or decreases the expression of the reporter protein thereby identifying a microRNA modulator. Antagonists identified by this screening assay are provided, as are methods for using the same to inhibit microRNA activity and prevent or treat disease.
• US20140255386A1
  申请人：——

  公开号：US20140255386A1

  公开（公告）日：2014-09-11