2-(2-Aminoacetyl)oxyethyl-trimethylazanium

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(2-Aminoacetyl)oxyethyl-trimethylazanium
• 化学式: C7H17N2O2+
• 分子量: 161.22
• InChiKey: QJOSIAWZYPKGND-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  11
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.3
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Compounds for delivering amino acids or peptides with antioxidant activity into mitochondria and use thereof
  申请人：Sheu Shey-Shing

  公开号：US20060160748A1

  公开（公告）日：2006-07-20

  Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

  本发明揭示了一种含有单个氨基酸、肽或其衍生物的化合物，该化合物可选择性地传递到细胞的线粒体。本发明的化合物表现出抗氧化活性，从而减少细胞内的反应性氧化物种。这些化合物对于抑制体内和体外氧化应激引起的细胞损伤或死亡非常有用。此外，本发明还揭示了这些化合物的合成方法。
• Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria and Use Thereof
  申请人：Sheu Shey-Shing

  公开号：US20090298782A1

  公开（公告）日：2009-12-03

  Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

  本发明揭示了包含单个氨基酸、多肽或其衍生物的化合物，这些化合物可选择性地传递到细胞的线粒体中。本发明的化合物表现出抗氧化活性，从而减少细胞中的反应性氧化物。这些化合物对于抑制体内和体外氧化应激诱导的细胞损伤或死亡非常有用。此外，还揭示了这些化合物的合成方法。
• Compounds for Delivering Amino Acids or Peptides with Antioxidant Activity into Mitochondria
  申请人：Sheu Shey-Shing

  公开号：US20110257107A1

  公开（公告）日：2011-10-20

  Disclosed are compounds containing single amino acids, peptides, or derivatives thereof which are selectively delivered to the mitochondria of a cell. Compounds of the invention exhibit antioxidant activity thereby reducing reactive oxygen species in cells. These compounds are useful for inhibiting oxidative stress-induced cell injury or death both in vivo and ex vivo. In addition, methods for the synthesis of these compounds are disclosed.

  本发明涉及包含单个氨基酸、肽或其衍生物的化合物，这些化合物能够选择性地传递到细胞的线粒体。本发明的化合物表现出抗氧化活性，从而减少细胞内的反应性氧化物种。这些化合物对于抑制氧化应激诱导的细胞损伤或死亡在体内和体外均有用。此外，本发明还揭示了这些化合物的合成方法。
• COMPOUNDS FOR DELIVERING AMINO ACIDS OR PEPTIDES WITH ANTIOXIDANT ACTIVITY INTO MITOCHONDRIA AND USE THEREOF
  申请人：UNIVERSITY OF ROCHESTER

  公开号：EP1691818A2

  公开（公告）日：2006-08-23
• EP1691818A4
  申请人：——

  公开号：EP1691818A4

  公开（公告）日：2007-01-24