3-(4-Methylmorpholine-1,4-diium-4-yl)propane-1-sulfonate

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 3-(4-Methylmorpholine-1,4-diium-4-yl)propane-1-sulfonate
• 英文别名: 3-(4-methylmorpholine-1,4-diium-4-yl)propane-1-sulfonate
• 化学式: C8H18NO4S+
• 分子量: 224.3
• InChiKey: OUBXNWVHYCHHDP-UHFFFAOYSA-O

计算性质

• 辛醇/水分配系数(LogP)：
  -0.9
• 重原子数：
  14
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  1.0
• 拓扑面积：
  72
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• Compositions and methods for analyzing biomolecules using mass spectroscopy
  申请人：Pope Marshall Robert

  公开号：US20060214104A1

  公开（公告）日：2006-09-28

  Compositions and methods for mass spectroscopy are disclosed. The compositions and methods relate to the analysis of proteins and other biopolymers using mass spectroscopy, particularly matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS).

  本发明揭示了用于质谱分析的组合物和方法。所述组合物和方法涉及使用质谱分析分析蛋白质和其他生物高分子，尤其是基质辅助激光解吸飞行时间质谱（MALDI-TOF MS）。
• Novel benzothiazepine and bensothiepine compounds
  申请人：Sasahara Takehiko

  公开号：US20070190041A1

  公开（公告）日：2007-08-16

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substitutent:

  提供了一种药物，可用作治疗和预防高脂血症的治疗剂和预防剂，以及一种药物，可用作治疗和预防与胆汁淤积有关的肝脏疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的治疗剂和预防剂，以及一种药物，可用作治疗和预防肥胖症、脂肪肝和脂肪性肝炎的治疗剂和预防剂。化合物的苯并噻吩或苯并噻环代表如下式（1A），具有硫酰胺键和季铵取代基：
• Novel quaternary ammonium compounds
  申请人：Sasahara Takehiko

  公开号：US20070203115A1

  公开（公告）日：2007-08-30

  A method for inhibiting ileal bile acid transporter activity in a subject, comprising administering to said subject an effective amount of a compound represented by formula (1):

  一种抑制回肠胆汁酸转运蛋白活性的方法，包括向该受试者施用一种由式（1）所代表的化合物的有效量：
• Compositions and Methods for Analyzing Biomolecules Using Mass Spectroscopy
  申请人：Pope Robert Marshall

  公开号：US20100187475A1

  公开（公告）日：2010-07-29

  Compositions and methods for mass spectroscopy are disclosed. The compositions and methods relate to the analysis of proteins and other biopolymers using mass spectroscopy, particularly matrix-assisted laser desorption time-of-flight mass spectrometry (MALDI-TOF MS).

  本发明涉及质谱分析的组合物和方法。这些组合物和方法涉及使用质谱分析技术对蛋白质和其他生物高分子进行分析，特别是基质辅助激光解吸飞行时间质谱（MALDI-TOF MS）技术。
• NOVEL BENZOTHIAZEPINE AND BENZOTHIEPINE COMPOUNDS
  申请人：SASAHARA Takehiko

  公开号：US20120015925A1

  公开（公告）日：2012-01-19

  A pharmaceutical useful as a therapeutic agent and a preventive agent for hyperlipemia, and a pharmaceutical useful as a therapeutic agent and a preventive agent for hepatic disorders associated with cholestasis, particularly, primary biliary cirrhosis and primary sclerosing cholangitis, and a pharmaceutical useful as a therapeutic agent and a preventive agent for obesity, fatty liver and steatohepatitis are provided. A benzothiazepine or benzothiepine compound represented by the following formula (1A) having a thioamide bond and a quaternary ammonium substituent:

  提供了一种作为治疗剂和预防剂用于高脂血症的药物，以及一种作为治疗剂和预防剂用于与胆汁淤积相关的肝疾病，特别是原发性胆汁性肝硬化和原发性硬化性胆管炎的药物，以及一种作为治疗剂和预防剂用于肥胖症、脂肪肝和脂肪性肝炎的药物。该药物是一种具有硫酰胺键和季铵基取代基的苯并噻吩或苯并噻吩化合物，其化学式为（1A）。