2-[2-(Phenylmethoxycarbonylamino)propanoylamino]butanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[2-(Phenylmethoxycarbonylamino)propanoylamino]butanedioic acid
• 化学式: C₁₅H₁₈N₂O₇
• 分子量: 338.31
• InChiKey: ZEMLEJZWLPVYOC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.3
• 重原子数：
  24
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  142
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES
  申请人：Idun Pharmaceuticals, Inc.

  公开号：EP1351975A2

  公开（公告）日：2003-10-15
• [EN] C-TERMINAL MODIFIED OXAMYL DIPEPTIDES AS INHIBITORS OF THE ICE/CED-3 FAMILY OF CYSTEINE PROTEASES<br/>[FR] OXAMYL DIPEPTIDES MODIFIES C-TERMINAL EN TANT QU'INHIBITEURS DE LA FAMILLE ICE/CED-3 DES CISTEINES PROTEASES
  申请人：IDUN PHARMACEUTICALS INC

  公开号：WO2002057298A2

  公开（公告）日：2002-07-25

  This invention is directed to novel oxamyl dipeptide ICE/ced-3 family inhibitor compounds. The invention is also directed to pharmaceutical compositions containing these compounds, as well as to the use of such compositions in the treatment of patients suffering inflammatory, autoimmune and neurodegenerative diseases, for the prevention of ischemic injury, and for the preservation of organs that are to undergo a transplantation procedure.