2-n-Amyl-thiazolidin-4-carbonsaeure | 69588-05-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-n-Amyl-thiazolidin-4-carbonsaeure
• 英文别名: 2-pentyl-thiazolidine-4-carboxylic acid；N,S-hexane-1,1-diyl-cysteine；2-pentyl-1,3-thiazolidin-3-ium-4-carboxylate
• CAS: 69588-05-2
• 化学式: C₉H₁₇NO₂S
• mdl: MFCD11198617
• 分子量: 203.305
• InChiKey: YAHGGWNXWOIXJD-UHFFFAOYSA-N

物化性质

• 沸点：
  366.5±37.0 °C(Predicted)
• 密度：
  1.107±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.1
• 重原子数：
  13
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.888
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS
  申请人：Miller Duane D.

  公开号：US20080255213A1

  公开（公告）日：2008-10-16

  Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides having a structure where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.

  具有结构的取代噻唑烷酮羧酸酰胺和取代噻唑烷羧酸酰胺，其中各种取代基如规范中定义。还披露了制备这些化合物的方法、含有这些化合物的药物组合物，以及它们的用途，特别是用于治疗或预防癌症。
• COMPOUNDS FOR THE TREATMENT OF CANCER
  申请人：University of Tennessee Research Foundation

  公开号：EP2303021A2

  公开（公告）日：2011-04-06
• [EN] COMBINATION THERAPY FOR ADDICTION DISORDERS<br/>[FR] TRAITEMENT THÉRAPEUTIQUE COMBINÉ D'UNE ADDICTION
  申请人：UNIV MINNESOTA

  公开号：WO2008008380A1

  公开（公告）日：2008-01-17

  [EN] The present invention provides a therapeutic method comprising administering at least one opioid receptor antagonist and at least one glutathione-increasing agent to an individual afflicted with an addiction disorder, in amounts that are effective to eliminate or reduce at least one symptom of said addiction disorder.
  [FR] La présente invention concerne un traitement thérapeutique comprenant l'administration à un patient souffrant d'une addiction d'au moins un antagoniste du récepteur opioïde et d'au moins un agent augmentant le glutathion, dans des quantités efficaces pour éliminer ou réduire au moins un symptôme de ladite addiction.
• [EN] THIAZOLIDINONE AMIDES, THIAZOLIDINE CARBOXYLIC ACID AMIDES, AND SERINE AMIDES, INCLUDING POLYAMINE CONJUGATES THEREOF, AS SELECTIVE ANTI-CANCER AGENTS<br/>[FR] AMIDES DE THIAZOLIDINONE, AMIDES D'ACIDE CARBOXYLIQUE DE THIAZOLIDINE ET AMIDES DE SÉRINE, Y COMPRIS LEURS CONJUGUÉS AVEC LA POLYAMINE, UTILISABLES EN TANT QU'AGENTS ANTICANCÉREUX SÉLECTIFS
  申请人：UNIV TENNESSEE RES FOUNDATION

  公开号：WO2008128179A1

  公开（公告）日：2008-10-23

  [EN] Substituted thiazolidinone carboxylic acid amides and substituted thiazolidine carboxylic acid amides having a structure (A) or (B) or where the various substituent groups are as defined in the specification. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.
  [FR] La présente invention concerne des amides d'acide carboxylique de thiazolidinone substitués et des amides d'acide carboxylique de thiazolidine substitués de structure (A) ou (B) ou d'une structure dans laquelle les divers groupes substituants sont tels que définis dans le mémoire descriptif. Elle concerne également des procédés de fabrication de ces composés, des compositions pharmaceutiques contenant ces composés, ainsi que leur utilisation, en particulier dans le cadre du traitement ou de la prévention des cancers.
• [EN] COMPOUNDS FOR THE TREATMENT OF CANCER<br/>[FR] COMPOSÉS DESTINÉS À TRAITER LE CANCER
  申请人：UNIV TENNESSEE RES FOUNDATION

  公开号：WO2010074776A2

  公开（公告）日：2010-07-01

  Compounds according to formula (I) are disclosed, (I), where Q is S, N, or O; X is optional, and can be O=, S=, =N-NH2, =N-OH, or -OH; Y is optional and can be -N(H)-, O, or C1 to C20 hydrocarbon; and R1 and R2 are each independently substituted or unsubstituted single-, fused- or multiple-ring aryl or (hetero)cyclic ring systems. Methods of making these compounds, pharmaceutical compositions containing the compounds, and their use, particularly for treating or preventing cancer, are also disclosed.