2-methylbutyryl-CoA

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-methylbutyryl-CoA
• 英文别名: S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-methylbutanethioate
• 化学式: C₂₆H₄₄N₇O₁₇P₃S
• 分子量: 851.7
• InChiKey: LYNVNYDEQMMNMZ-PCLZRLGGSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  54
• 可旋转键数：
  22
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  389
• 氢给体数：
  9
• 氢受体数：
  22

文献信息

• METHODS OF TREATING DISORDERS ASSOCIATED WITH CASTOR
  申请人：St. Jude Children's Research Hospital, Inc.

  公开号：EP3731859A1

  公开（公告）日：2020-11-04
• PRODUCTION OF MACROCYCLIC KETONES IN RECOMBINANT HOSTS
  申请人：TAKASAGO INTERNATIONAL CORPORATION

  公开号：US20200347412A1

  公开（公告）日：2020-11-05

  The invention relates to recombinant microorganisms and methods for producing macrocyclic ketones and macrocyclic ketone precursors.
• COMPOSITIONS AND METHODS FOR MODULATING METABOLIC REGULATORS OF T CELL PATHOGENICITY
  申请人：The Broad Institute, Inc.

  公开号：US20220142948A1

  公开（公告）日：2022-05-12

  The subject matter disclosed herein is generally directed to modulation of Th17 differentiation and pathogenicity by use of metabolic targets. The metabolic targets are the molecules of the polyamine pathway or glycolysis pathway. Modulation of the polyamine pathway can shift Th17 pathogenicity and shift the transcriptome of Th17 cells to a Treg or Th1 transcriptome. The polyamine analogue DFMO can be used to modulate an inflammatory response. Inhibitors of enzymes in the glycolysis pathway can shift Th17 pathogenicity.