3-oxoadipyl-CoA; (Acyl-CoA); [M+H]+

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 3-oxoadipyl-CoA; (Acyl-CoA); [M+H]+
• 英文别名: 6-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethylsulfanyl]-4,6-dioxohexanoic acid
• 化学式: C₂₇H₄₂N₇O₂₀P₃S
• 分子量: 909.6
• InChiKey: VKKKAAPGXHWXOO-RHRWFGCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -6.4
• 重原子数：
  58
• 可旋转键数：
  25
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.63
• 拓扑面积：
  443
• 氢给体数：
  10
• 氢受体数：
  25

文献信息

• GENE-MODIFIED MICROORGANISM FOR PRODUCING 3-HYDROXYADIPIC ACID, -HYDROMUCONIC ACID AND/OR ADIPIC ACID, AND PRODUCTION METHOD FOR SAID CHEMICAL PRODUCTS
  申请人：Toray Industries, Inc.

  公开号：EP3719121A1

  公开（公告）日：2020-10-07

  Disclosed is a genetically modified microorganism into which a nucleic acid encoding an enzyme that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA is introduced. In the genetically modified microorganism, a nucleic acid encoding any one of the polypeptides described in (a) to (c) below is introduced or expression of the polypeptide is enhanced: (a) a polypeptide composed of an amino acid sequence represented by any one of SEQ ID NOs: 1 to 6 and 213, (b) a polypeptide composed of the same amino acid sequence as any one of the amino acid sequences, except that one or several amino acids are substituted, deleted, inserted, and/or added, and having enzymatic activity that catalyzes a reaction to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA, and (c) a polypeptide composed of an amino acid sequence with a sequence identity of not less than 70% to any one of the amino acid sequences and having activity to reduce 3-oxoadipyl-CoA to 3-hydroxyadipyl-CoA.

  本发明公开了一种转基因微生物，在该微生物中引入了编码一种酶的核酸，该酶可催化将 3-氧代二酰-CoA 还原为 3-羟基二酰-CoA 的反应。在转基因微生物中，引入编码下述(a)至(c)中所述任何一种多肽的核酸或增强该多肽的表达：(a)由 SEQ ID NO：1至6和213中任何一个所代表的氨基酸序列组成的多肽，(b)由与上述氨基酸序列中任何一个相同的氨基酸序列组成的多肽，但其中一个或几个氨基酸被取代、删除、插入和/或添加，并具有催化将3-氧代二酰-CoA还原为3-羟基二酰-CoA的反应的酶活性，以及(c)由与上述氨基酸序列中任何一个相同的氨基酸序列组成的多肽，但其中一个或几个氨基酸被取代、删除、插入和/或添加、(c) 由氨基酸序列组成的多肽，该氨基酸序列与上述任何一个氨基酸序列的序列同一性不低于 70%，并具有将 3-氧代二磷酰-CoA 还原成 3-羟基二磷酰-CoA 的活性。
• GENETIC KNOCKOUTS IN WOOD-LJUNGDAHL MICROORGANISMS
  申请人：Lanzatech, Inc.

  公开号：EP3688169A2

  公开（公告）日：2020-08-05
• [EN] GENETIC KNOCKOUTS IN WOOD-LJUNGDAHL MICROORGANISMS<br/>[FR] BLOQUAGES GÉNÉTIQUES CHEZ LES MICRO-ORGANISMES À VOIE DE WOOD-LJUNGDAHL
  申请人：LANZATECH INC

  公开号：WO2019068011A2

  公开（公告）日：2019-04-04

  The invention provides genetically engineered Wood-Ljungdahl microorganisms comprising one or more disrupted genes to strategically divert carbon flux away from nonessential or undesirable products and towards products of interest. The expression strategies of the invention enable the production of useful fuels and chemicals from gaseous substrates, such as carbon monoxide, carbon dioxide, and/or hydrogen.