butyrylcarnitine | 1492-26-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: butyrylcarnitine
• 英文别名: O-Butanoylcarnitine；3-butanoyloxy-4-(trimethylazaniumyl)butanoate
• CAS: 1492-26-8
• 化学式: C₁₁H₂₁NO₄
• 分子量: 231.292
• InChiKey: QWYFHHGCZUCMBN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.2
• 重原子数：
  16
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.82
• 拓扑面积：
  66.4
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• [EN] L-CARNITINE AND ALKANOYL L-CARNITINE PHYTATES AND PROCESS FOR PREPARING THE SAME<br/>[FR] PHYTATES DE L-CARNITINE ET D'ALCANOYLE L-CARNITINE, ET LEUR PROCÉDÉ DE PRÉPARATION
  申请人：SCIAN LAB LLC

  公开号：WO2010005465A1

  公开（公告）日：2010-01-14

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1 :1 to 6:1, wherein: n = 1-6; R1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和烷酰基L-肉碱盐与一般公式(I)的植酸，以及制备这些化合物的过程，其中L-肉碱或其烷酰衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n = 1-6；R1为植酸阴离子；R为氢、具有2-12个碳原子的直链烷酰基团或具有2-12个碳原子的支链烷酰基团。
• L-carnitine and alkanoyl L-carnitine phytates and process for preparing the same
  申请人：Chen Jian

  公开号：US20100317890A1

  公开（公告）日：2010-12-16

  Salts of L-carnitine and alkanoyl L-carnitines with phytic acid of general formula (I), and the process of preparing the same, wherein the mole ratio between the L-carnitine or its alkanoyl derivatives cation and phytic acid anion be within the range of 1:1 to 6:1, wherein: n=1-6; R 1 is the phytate anion; R is either hydrogen, a straight alkanoyl group having 2-12 carbon atoms or a branched-chain alkanoyl group having 2-12 carbon atoms.

  L-肉碱盐和辛酰基L-肉碱盐与通式(I)的植酸，以及其制备方法，其中L-肉碱或其辛酰基衍生物阳离子与植酸阴离子之间的摩尔比在1:1至6:1的范围内，其中：n=1-6；R1是植酸阴离子；R是氢，具有2-12个碳原子的直链辛酰基或具有2-12个碳原子的支链辛酰基。
• [EN] ORGANIC NUTRIENT SALTS, METHODS OF PREPARATION AND USES<br/>[FR] SELS NUTRITIFS ORGANIQUES, LEURS PROCÉDÉS DE PRÉPARATION ET LEURS UTILISATIONS
  申请人：BELLUS HEALTH INT LTD

  公开号：WO2010054485A1

  公开（公告）日：2010-05-20

  The current application relates to organic nutrient salts comprised of 3-amino-1-propanesulfonic acid (homotaurine) and an organic cationic component which contributes to the therapeutic and/or nutritional value of the salts. The application also relates to the method of preparing the organic nutrient salts and the use of the same as nutraceuticals for neuroprotection and for improving or protecting cognitive and memory functions.

  这项当前的申请涉及由3-氨基-1-丙磺酸（同牛磺酸）和一个有机阳离子组分组成的有机营养盐，该组分有助于盐的治疗和/或营养价值。该申请还涉及制备有机营养盐的方法以及将其用作神经保护的营养保健品，以改善或保护认知和记忆功能。
• METHODS FOR USING AND BIOMARKERS FOR AMPK-ACTIVATING COMPOUNDS
  申请人：Hitoshi Yasumichi

  公开号：US20150087673A1

  公开（公告）日：2015-03-26

  Disclosed are methods of using AMPK-activating compounds, for example, in the treatment of cancer and disorders of vascular flow. Also disclosed are biomarkers for AMPK and uses thereof, for example, in the diagnosis and treatment of AMPK-linked disorders. In certain embodiments, the AMPK-activating compounds have the structural formula wherein E, J, T, D 1 , D 2 , D 3 , the ring system denoted by “B”, T, R 3 , R 4 , w and x are as described herein.

  本文公开了使用AMPK激活化合物的方法，例如在癌症和血管流动障碍的治疗中的应用。还公开了AMPK的生物标志物及其用途，例如在AMPK相关疾病的诊断和治疗中的应用。在某些实施例中，AMPK激活化合物具有以下结构式，其中E、J、T、D1、D2、D3、由“B”表示的环系统、T、R3、R4、w和x如本文所述。
• [EN] ANIONIC HYDROGEL MATRICES WITH PH DEPENDENT MODIFIED RELEASE AS DRUG CARRIERS<br/>[FR] MATRICES D'HYDROGEL ANIONIQUE A LIBERATION MODIFIEE DEPENDANT DU PH COMME VECTEURS DE MEDICAMENT
  申请人：SIGMA TAU IND FARMACEUTI

  公开号：WO2005094792A1

  公开（公告）日：2005-10-13

  Compositions with pH-dependent modified release are described, consisting of hydrogel matrices containing one or more active ingredients, in which said matrices are suitable for releasing said active ingredients in a prolonged manner in given sites of the body.

  本发明描述了具有pH依赖性改性释放的组合物，包括含有一种或多种活性成分的水凝胶基质，其中所述基质适用于在身体的给定部位以延长的方式释放所述活性成分。