methacrylyl-CoA; (Acyl-CoA); [M+H]+

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: methacrylyl-CoA; (Acyl-CoA); [M+H]+
• 英文别名: S-[2-[3-[[4-[[[(2R,3S,4R,5R)-5-(6-aminopurin-9-yl)-4-hydroxy-3-phosphonooxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-hydroxyphosphoryl]oxy-2-hydroxy-3,3-dimethylbutanoyl]amino]propanoylamino]ethyl] 2-methylprop-2-enethioate
• 化学式: C₂₅H₄₀N₇O₁₇P₃S
• 分子量: 835.6
• InChiKey: NPALUEYCDZWBOV-NNYIDDMCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.6
• 重原子数：
  53
• 可旋转键数：
  21
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  389
• 氢给体数：
  9
• 氢受体数：
  22

文献信息

• EIN VERFAHREN ZUR HERSTELLUNG VON METHACRYLSÄURE ODER METHACRYLSÄUREESTERN
  申请人：Evonik Röhm GmbH

  公开号：EP2152659B1

  公开（公告）日：2013-04-24
• MICROBIOLOGICAL PRODUCTION OF 3-HYDROXYISOBUTYRIC ACID
  申请人：Marx Achim

  公开号：US20100068773A1

  公开（公告）日：2010-03-18

  The present invention relates to a cell which has been modified in comparison with its wild type in such a way that it is capable of forming more, by comparison with its wild, 3-hydroxyisobutyric acid or poly-hydroxyalkanoates based on 3-hydroxyisobutyric acid via methylmalonate-semialdehyde or 3-hydroxybutyryl-coenzyme A as precursors. The invention also relates to a method of generating a genetically modified cell, to the genetically modified cell obtainable by these methods, to a method of producing 3-hydroxyisobutyric acid or polyhydroxyalkanoates based on 3-hydroxyisobutyric acid, to a method of producing methacrylic acid or methacrylic esters, and to a method of producing polymethacrylic acid or polymethacrylic esters. The present invention furthermore relates to an isolated DNA, to a vector, to the use of this vector for transforming a cell, to a transformed cell, and to a polypeptide.