5-Methyldeoxycytidine 5'-(trihydrogen diphosphate)

• 分子结构分类: 有机化合物 - 有机氧化合物 - 有机含氧阴离子化合物
• 英文名称: 5-Methyldeoxycytidine 5'-(trihydrogen diphosphate)
• 英文别名: [(2R,3S,5R)-5-(4-amino-5-methyl-2-oxopyrimidin-1-yl)-3-hydroxyoxolan-2-yl]methyl phosphono hydrogen phosphate
• 化学式: C₁₀H₁₇N₃O₁₀P₂
• 分子量: 401.2
• InChiKey: SHFOWZBOBJJZAP-XLPZGREQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4
• 重原子数：
  25
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  201
• 氢给体数：
  5
• 氢受体数：
  10

文献信息

• BARCODING TECHNOLOGY FOR SEQUENCING OF NUCLEIC ACID MOLECULES
  申请人：UMC Utrecht Holding B.V.

  公开号：EP3878972A1

  公开（公告）日：2021-09-15

  The invention relates to barcodes that have both unique and shared sequences. The barcodes are easy to sequence and to identify. In one aspect the invention provides a collection of barcoded nucleic acid molecules wherein each barcode comprises a sequence that is shared with the other barcodes in the collection and a sequence that is not shared with the other barcodes in the collection wherein the nucleotide residues that encode the non-shared sequence are interspersed with the nucleotide residues that encode the shared sequence. The invention also provides kits and method for sequencing nucleic acids.

  本发明涉及具有唯一序列和共享序列的条形码。这些条形码易于测序和识别。在一个方面，本发明提供了一个条形码核酸分子集合，其中每个条形码包括一个与集合中其他条形码共享的序列和一个与集合中其他条形码不共享的序列，其中编码不共享序列的核苷酸残基与编码共享序列的核苷酸残基穿插在一起。本发明还提供了用于核酸测序的试剂盒和方法。
• Hairpin loop method for double strand polynucleotide sequencing using transmembrane pores
  申请人：Oxford Nanopore Technologies Ltd.

  公开号：US10597713B2

  公开（公告）日：2020-03-24

  The invention relates to a new method of sequencing a double stranded target polynucleotide. The two strands of the double stranded target polynucleotide are linked by a bridging moiety. The two strands of the target polynucleotide are separated using a polynucleotide binding protein and the target polynucleotide is sequenced using a transmembrane pore.

  本发明涉及一种对双链目标多核苷酸进行测序的新方法。双链目标多核苷酸的两条链由桥接分子连接。利用多核苷酸结合蛋白将目标多核苷酸的两条链分开，并利用跨膜孔对目标多核苷酸进行测序。
• Method of analyzing post-translational modifications
  申请人：OXFORD UNIVERSITY INNOVATION LIMITED

  公开号：US10712254B2

  公开（公告）日：2020-07-14

  The invention relates to a new method of determining the presence, absence, number or position(s) of one or more post-translational modifications in a peptide, polypeptide or protein. The invention uses transmembrane pores.

  本发明涉及一种确定肽、多肽或蛋白质中一种或多种翻译后修饰存在、不存在、数量或位置的新方法。本发明使用跨膜孔。
• Aptamer method
  申请人：OXFORD NANOPORE TECHNOLOGIES LIMITED

  公开号：US10739341B2

  公开（公告）日：2020-08-11

  The invention relates to a new method of determining in a sample the presence or absence of one or more analyte members of a group of two or more analytes. The invention therefore relates to a multiplex assay for determining the presence or absence of each analyte in a group of multiple analytes. The assay uses aptamers and transmembrane pores.

  本发明涉及一种新方法，用于确定样品中是否存在由两种或两种以上分析物组成的一组分析物中的一种或多种分析物。因此，本发明涉及一种多重测定法，用于确定多个分析物群中每个分析物的存在或不存在。该检测方法使用了适配体和跨膜孔。
• Method for treating chronic intestinal inflammation and inflammatory bowel disease by administering antagonists of Oncostatin-M (OSM) and/or antagonists of OSM receptor-beta (OSMR)
  申请人：Oxford University Innovation Limited

  公开号：US10822406B2

  公开（公告）日：2020-11-03

  The invention relates to methods of treating chronic intestinal inflammation and/or inflammatory bowel disease by administering an antagonist of oncostatin-M (OSM) and/or OSM receptor-β (OSMR). The invention also relates to methods for diagnosing or prognosing chronic intestinal inflammation and/or inflammatory bowel disease in an individual and for predicting whether or not an individual will respond to an anti-TNFα therapy. The methods comprise measuring OSM and/or OSMR in the individual.

  本发明涉及通过施用oncOStatin-M（OSM）和/或OSM受体-β（OSMR）的拮抗剂来治疗慢性肠道炎症和/或炎症性肠病的方法。 本发明还涉及诊断或预后个体慢性肠道炎症和/或炎症性肠病以及预测个体是否会对抗肿瘤坏死因子α疗法产生反应的方法。 这些方法包括测量个体的OSM和/或OSMR。