Oxaloglutarate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Oxaloglutarate
• 英文别名: 1-oxobutane-1,2,4-tricarboxylic acid
• 化学式: C₇H₈O₇
• 分子量: 204.13
• InChiKey: PYOHERBGXSPHQI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  129
• 氢给体数：
  3
• 氢受体数：
  7

文献信息

• Use of adenoviral E4 reading frames to improve expression of a gene of interest
  申请人：TRANSGENE S.A.

  公开号：EP0974668A1

  公开（公告）日：2000-01-26

  Described are recombinant adenoviral vectors retaining sufficient E4 sequences to improve the expression and/or persistence of expression of a gene of interest. Furthermore, the invention describes the use of a polynucleotide encoding one or more ORF(s) of the E4 region of an adenovirus selected from ORF1, ORF2, ORF3, ORF4, ORF3/4, ORF6/7, ORF6 and ORF7 taken individually or in combination, to improve the expression and/or persistence of expression of a gene of interest operably linked to regulatory elements and inserted into an expression vector. Finally, a host cell, a composition, an infectious viral particle comprising such a polynucleotide or adenoviral vector, a method for preparing said viral particle as well as their therapeutic use are described.

  本发明描述的重组腺病毒载体保留了足够的 E4 序列，以提高相关基因的表达和/或表达的持久性。此外，本发明还描述了一种多核苷酸的用途，该多核苷酸编码选自 ORF1、ORF2、ORF3、ORF4、ORF3/4、ORF6/7、ORF6 和 ORF7 的腺病毒 E4 区的一个或多个 ORF，可单独或组合使用，以改善与调控元件可操作连接并插入表达载体的相关基因的表达和/或持续表达。最后，还介绍了一种宿主细胞、一种组合物、一种包含这种多核苷酸或腺病毒载体的传染性病毒颗粒、一种制备所述病毒颗粒的方法以及它们的治疗用途。
• Use of adenoviral e4 reading frames to improve expression of a gene of interest
  申请人：TRANSGENE S.A.

  公开号：EP1199368A2

  公开（公告）日：2002-04-24

  Described are recombinant adenoviral vectors retaining sufficient E4 sequences to improve the expression and/or persistence of expression of a gene of interest. Furthermore, the invention describes the use of a polynucleotide encoding one or more ORF(s) of the E4 region of an adenovirus selected from ORF1, ORF2, ORF3, ORF4, ORF3/4, ORF6/7, ORF6 and ORF7 taken individually or in combination, to improve the expression and/or persistence of expression of a gene of interest operably linked to regulatory elements and inserted into an expression vector. Finally, a host cell, a composition, an infectious viral particle comprising such a polynucleotide or adenoviral vector, a method for preparing said viral particle as well as their therapeutic use are described.

  本发明描述的重组腺病毒载体保留了足够的 E4 序列，以提高相关基因的表达和/或表达的持久性。此外，本发明还描述了一种多核苷酸的用途，该多核苷酸编码选自 ORF1、ORF2、ORF3、ORF4、ORF3/4、ORF6/7、ORF6 和 ORF7 的腺病毒 E4 区的一个或多个 ORF，可单独或组合使用，以改善与调控元件可操作连接并插入表达载体的相关基因的表达和/或持续表达。最后，还介绍了一种宿主细胞、一种组合物、一种包含这种多核苷酸或腺病毒载体的传染性病毒颗粒、一种制备所述病毒颗粒的方法以及它们的治疗用途。
• Microperfusive electrical stimulation
  申请人：Zoll Medical Corporation

  公开号：EP1588736A2

  公开（公告）日：2005-10-26

  A method of treating a patient in cardiac arrest (e.g., in fibrillation, electrochemical dissociation, or asystole), the method comprising delivering an agent for enhancement of cardiac function to the coronary arteries of the patient; and microperfusing the patient's cardiac tissue by electromagnetically stimulating the cardiac tissue at an energy level below a threshold sufficient to defibrillate the heart.

  一种治疗心脏骤停（例如，纤颤、电化学解离或休克）患者的方法，该方法包括向患者的冠状动脉输送一种增强心脏功能的药剂；以及通过电磁刺激心脏组织，使其能量水平低于足以对心脏进行除颤的阈值，从而对患者的心脏组织进行微灌注。
• A method of diagnosing an asthma disease state
  申请人：The Governors of the University of Alberta

  公开号：EP2685259A1

  公开（公告）日：2014-01-15

  There is provided. a method of diagnosing an asthma disease state in a subject comprising (a) providing an urine sample, (b) measuring he concentration of certain metabolites in the sample, (c) providing a concentration profile differentiating between a chronic stable asthma disease state, an exacerbated disease state, and non-disease state using respective associated concentration profile values of said metabolites and (d) comparing the concentration values with the associated concentration profile values.

  提供了一种诊断受试者哮喘疾病状态的方法，该方法包括：(a) 提供尿液样本；(b) 测量样本中某些代谢物的浓度；(c) 利用所述代谢物各自的相关浓度曲线值，提供区分慢性稳定哮喘疾病状态、加重疾病状态和非疾病状态的浓度曲线；(d) 将浓度值与相关浓度曲线值进行比较。
• A METHOD OF DIAGNOSING A RESPIRATORY DISEASE
  申请人：The Governors of the University of Alberta

  公开号：EP2331955A1

  公开（公告）日：2011-06-15