2-hydroxy-2H-pyran-4,6-dicarboxylic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 2-hydroxy-2H-pyran-4,6-dicarboxylic acid
• 化学式: C₇H₆O₆
• 分子量: 186.12
• InChiKey: MLOJGZHQNWCBAC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  104
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• Conversion of biomass to useful intermediates
  申请人：Alliance for Sustainable Energy, LLC

  公开号：US10253338B2

  公开（公告）日：2019-04-09

  An aspect of the present disclosure is a microbial cell that includes a genetic modification resulting in the expression of a deficient form of an endogenous dioxygenase, and a gene encoding an exogenous dioxygenase and a promoter sequence, where the endogenous dioxygenase includes PcaH and PcaG, the exogenous dioxygenase includes LigA and LigB, the microbial cell is capable of growth utilizing at least one of a cellulose decomposition molecule or a lignin decomposition molecule, and the microbial cell is capable of producing 2-hydroxy-2H-pyran-4,6-dicarboxylic acid.

  本公开的一个方面是一种微生物细胞，它包括导致表达内源二氧 化酶缺陷形式的遗传修饰，以及编码外源二氧 化酶的基因和启动子序列，其中内源二氧 化酶包括 PcaH 和 PcaG、外源二氧化酶包括 LigA 和 LigB，微生物细胞能够利用纤维素分解分子或木质素分解分子中的至少一种进行生长，微生物细胞能够产生 2-羟基-2H-吡喃-4,6-二羧酸。
• Conversion of S-lignin compounds to useful intermediates
  申请人：Alliance for Sustainable Energy, LLC

  公开号：US11136601B2

  公开（公告）日：2021-10-05

  The present disclosure relates to a genetically modified microbial cell that includes a genetic modification resulting in the expression of a vanillate demethylase, where the microbial cell is capable of metabolizing at least one S-lignin decomposition molecule including at least one of syringate and/or 3-O-methyl gallate, and the genetically modified microbial cell is capable of producing gallate. In some embodiments of the present disclosure, the vanillate demethylase may include VanAB.

  本公开涉及一种转基因微生物细胞，它包括导致香草酸脱甲基酶表达的基因修饰，其中微生物细胞能够代谢至少一种S-木质素分解分子，包括丁香酸盐和/或3-O-甲基没食子酸盐中的至少一种，并且转基因微生物细胞能够产生没食子酸盐。在本公开的一些实施方案中，香草酸脱甲基酶可包括 VanAB。
• Engineered microorganisms for the production of intermediates and final products
  申请人：Alliance for Sustainable Energy, LLC

  公开号：US11518975B2

  公开（公告）日：2022-12-06

  The present disclosure relates to a non-naturally occurring microorganism that includes an endogenous genetic deletion that eliminates the expression of at least a pyruvate kinase, where the genetically modified prokaryotic microorganism is capable of producing 3-deoxy-D-arabino-heptulosonate-7-phosphate.

  本公开涉及一种非天然存在的微生物，它包括一种内源基因缺失，至少消除了丙酮酸激酶的表达，其中转基因原核微生物能够生产 3-脱氧-D-阿拉伯糖庚二酸-7-磷酸酯。
• CONVERSION OF BIOMASS TO USEFUL INTERMEDIATES
  申请人：Alliance for Sustainable Energy, LLC

  公开号：US20170275655A1

  公开（公告）日：2017-09-28

  An aspect of the present disclosure is a microbial cell that includes a genetic modification resulting in the expression of a deficient form of an endogenous dioxygenase, and a gene encoding an exogenous dioxygenase and a promoter sequence, where the endogenous dioxygenase includes PcaH and PcaG, the exogenous dioxygenase includes LigA and LigB, the microbial cell is capable of growth utilizing at least one of a cellulose decomposition molecule or a lignin decomposition molecule, and the microbial cell is capable of producing 2-hydroxy-2H-pyran-4,6-dicarboxylic acid.
• CONVERSION OF S-LIGNIN COMPOUNDS TO USEFUL INTERMEDIATES
  申请人：Alliance for Sustainable Energy, LLC

  公开号：US20200071731A1

  公开（公告）日：2020-03-05

  The present disclosure relates to a genetically modified microbial cell that includes a genetic modification resulting in the expression of a vanillate demethylase, where the microbial cell is capable of metabolizing at least one S-lignin decomposition molecule including at least one of syringate and/or 3-O-methyl gallate, and the genetically modified microbial cell is capable of producing gallate. In some embodiments of the present disclosure, the vanillate demethylase may include VanAB.