S-Octylglutathione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: S-Octylglutathione
• 英文别名: (2S)-2-amino-5-[[(2R)-1-(carboxymethylamino)-3-octylsulfanyl-1-oxopropan-2-yl]amino]-5-oxopentanoic acid
• 化学式: C₁₈H₃₃N₃O₆S
• 分子量: 419.5
• InChiKey: MJWCZWAVSJZQNL-KBPBESRZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  28
• 可旋转键数：
  17
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  184
• 氢给体数：
  5
• 氢受体数：
  8

ADMET

代谢

辛基谷胱甘肽是1-碘辛烷的人体代谢物。

Octyl-glutathione is a known human metabolite of 1-iodooctane.

来源:NORMAN Suspect List Exchange

文献信息

• Composition and methods for inhibition of metal corrosion for use in the oil and gas industry
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US10323327B2

  公开（公告）日：2019-06-18

  Corrosion inhibiting compositions and methods of inhibiting corrosion on a metal surface commonly used in the petroleum industry is disclosed. The corrosion inhibitor includes at least one azole, at least one polypeptide derived from amino acid, at least one intensifier preferably from metal halides, and at least one surfactant. The methods include combining effective amounts of the corrosion inhibitor composition and contacting a metal surface in aqueous environment commonly found in oil and gas industry. The composition is very effective against corrosion of metals in contact with aqueous media when used in a dosage as low as 50 ppm.

  本发明公开了抑制石油工业常用金属表面腐蚀的缓蚀组合物和方法。缓蚀剂包括至少一种唑、至少一种由氨基酸衍生的多肽、至少一种优选由金属卤化物衍生的增强剂和至少一种表面活性剂。方法包括将有效量的缓蚀剂组合物与石油和天然气工业中常见的水环境中的金属表面接触。当使用剂量低至 50 ppm 时，该组合物对与水介质接触的金属腐蚀非常有效。
• Targeted liposomal delivery of cGMP analogues
  申请人：Mireca Medicines GmbH

  公开号：US10322087B2

  公开（公告）日：2019-06-18

  The invention relates to means and methods of targeted drug delivery of therapeutic agent to and across the blood-ocular barrier. In particular, the invention relates to cyclic guanosine-3′, 5′-monophosphate analogs as therapeutic agent for treating retinal diseases. The cGMPSs targeted to the blood-ocular barrier by glutathione-based ligands that facilitate the specific binding to and enhanced internalization by glutathione transporters present on the blood-ocular barrier. The glutathione-based ligands are conjugated to nanocontainers such as liposomes encapsulating the cGMPSs.

  本发明涉及将治疗剂靶向输送到血眼屏障并穿过血眼屏障的手段和方法。特别是，本发明涉及环鸟苷-3′，5′-单磷酸类似物作为治疗视网膜疾病的治疗剂。环鸟苷-3′，5′-单磷酸类似物通过谷胱甘肽配体靶向血眼屏障，促进与存在于血眼屏障上的谷胱甘肽转运体的特异性结合和增强内化。谷胱甘肽配体与包裹 cGMPSs 的脂质体等纳米容器共轭。
• Method for inhibiting metal corrosion using a benzimidazole-containing composition
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US11124883B2

  公开（公告）日：2021-09-21

  Corrosion inhibiting compositions and methods of inhibiting corrosion on a metal surface commonly used in the petroleum industry is disclosed. The corrosion inhibitor includes at least one azole, at least one polypeptide derived from amino acid, at least one intensifier preferably from metal halides, and at least one surfactant. The methods include combining effective amounts of the corrosion inhibitor composition and contacting a metal surface in aqueous environment commonly found in oil and gas industry. The composition is very effective against corrosion of metals in contact with aqueous media when used in a dosage as low as 50 ppm.

  本发明公开了抑制石油工业常用金属表面腐蚀的缓蚀组合物和方法。缓蚀剂包括至少一种唑、至少一种由氨基酸衍生的多肽、至少一种优选由金属卤化物衍生的增强剂和至少一种表面活性剂。方法包括将有效量的缓蚀剂组合物与石油和天然气工业中常见的水环境中的金属表面接触。当使用剂量低至 50 ppm 时，该组合物对与水介质接触的金属腐蚀非常有效。
• Benzimidazole composition for metal corrosion inhibition
  申请人：KING FAHD UNIVERSITY OF PETROLEUM AND MINERALS

  公开号：US11124882B2

  公开（公告）日：2021-09-21

  Corrosion inhibiting compositions and methods of inhibiting corrosion on a metal surface commonly used in the petroleum industry is disclosed. The corrosion inhibitor includes at least one azole, at least one polypeptide derived from amino acid, at least one intensifier preferably from metal halides, and at least one surfactant. The methods include combining effective amounts of the corrosion inhibitor composition and contacting a metal surface in aqueous environment commonly found in oil and gas industry. The composition is very effective against corrosion of metals in contact with aqueous media when used in a dosage as low as 50 ppm.

  本发明公开了抑制石油工业常用金属表面腐蚀的缓蚀组合物和方法。缓蚀剂包括至少一种唑、至少一种由氨基酸衍生的多肽、至少一种优选由金属卤化物衍生的增强剂和至少一种表面活性剂。方法包括将有效量的缓蚀剂组合物与石油和天然气工业中常见的水环境中的金属表面接触。当使用剂量低至 50 ppm 时，该组合物对与水介质接触的金属腐蚀非常有效。
• Treatment of dandruff
  申请人：Unilever Home & Personal Care USA, Division of Conopco, Inc.

  公开号：US20020168327A1

  公开（公告）日：2002-11-14

  Dandruff and symptoms of dandruff can be treated using lipophilic agents or lipid precursor and/or promoters to strengthen the scalp. The lipophilic agents or lipid precursor and/or promoters are preferably used in conjunction with an antifungal agent which has activity against Malassezia spp, particularly Malassezia furfur . Suitable antifungal agents include those conventionally used for the treatment of dandruff including, for example, zinc pyrithrone (ZnPTO), octopirox and azole antifungal agents such as climbazole and ketocanazole. The antifungal agents may be used singularly or as a mixture of one or more antifungal agents.

  头皮屑和头皮屑症状可使用亲脂剂或脂质前体和/或促进剂来治疗，以增强头皮的功效。亲脂剂或脂质前体和/或促进剂最好与具有抗马拉色菌活性的抗真菌剂一起使用，特别是 糠秕马拉色菌 .合适的抗真菌剂包括传统上用于治疗头皮屑的抗真菌剂，例如吡蚜酮锌 (ZnPTO)、辛吡罗和唑类抗真菌剂，如爬山唑和酮康唑。这些抗真菌剂可单独使用，也可作为一种或多种抗真菌剂的混合物使用。