(2S)-6-amino-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-6-amino-2-[[(2S)-2-[[(2S)-2,6-diaminohexanoyl]amino]-3-(1H-imidazol-5-yl)propanoyl]amino]hexanoic acid
• 化学式: C₁₈H₃₃N₇O₄
• 分子量: 411.5
• InChiKey: FGMHXLULNHTPID-KKUMJFAQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.2
• 重原子数：
  29
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  202
• 氢给体数：
  7
• 氢受体数：
  8

文献信息

• Novel isozyme of autoclavable superoxide dismutase (SOD), a process for the identification and extraction of the SOD and use of the said SOD in cosmetic, food, and pharmaceutical compositions
  申请人：Council of Scientific & Industrial Research

  公开号：US20030064494A1

  公开（公告）日：2003-04-03

  The invention relates to a novel purified isozyme of an autoclavable superoxide dismutase extracted from the plant Potentilla astrisanguinea Lodd. Var. orgyrophylla, said isozyme having the following characteristics, O 2 −. scavenging activity remains same before and after autoclaving; scavenges O 2 −. from sub-zero temperature of −20° C. to high temperature of +80° C.; O 2 −. scavenging activity at 25° C. for 30 days without adding any stabilizing agent such as polyols or sugars; O 2 −. scavenging activity in the presence of saline (0.9% sodium chloride) to 61.8% of the control (without 0.9% sodium chloride), stable at 4° C. for at least 8 months; contamination free and infection free from any living micro- and/ or macro-organism after autoclaving; possesses temperature optima at 0° C.; possesses a molecular weight of 33 kD under non-denaturating conditions; possesses a molecular weight of 36 kD under denaturating conditions; has clear peaks in UV range at 268 and 275 nm; has an enzyme turnover number of 19.53×10 4 % per nmol per min at 0° C.; and requires Cu/Zn as a co-factor, method for the preparation of the purified isozyme of autoclavable superoxide dismutase and formulations containing the said autoclavable superoxide dismutase.

  本发明涉及一种新型的可自动灭菌超氧化物歧化酶纯化同工酶，该同工酶提取自植物 Potentilla astrisanguinea Lodd.Var. orgyrophylla、 所述同工酶具有以下特征，O 2 -. 清除活性在高压灭菌前后保持不变；清除 O 2 -. 从零下 20 摄氏度到 80 摄氏度以上的高温；O 2 -. 在不添加任何稳定剂（如多元醇或糖）的情况下，在 25° C 条件下持续 30 天的清除活性；O 2 -. 2 -. 在有生理盐水（0.9% 氯化钠）的情况下，清除活性为对照组（不含 0.9% 氯化钠）的 61.8%，在 4 摄氏度下稳定至少 8 个月；高压灭菌后无污染，无任何微生物和/或大型生物感染；在 0 摄氏度下具有最佳温度。在非饱和条件下，分子量为 33 kD；在变性条件下，分子量为 36 kD；在 268 和 275 nm 波长的紫外线范围内有清晰的峰值；酶周转次数为 19.53×10 4 需要 Cu/Zn 作为辅助因子。
• Hair growth stimulation with nitroxide and other radicals
  申请人：PROCTOR, Peter H.

  公开号：EP0327263B1

  公开（公告）日：1994-09-07
• US5470876A
  申请人：——

  公开号：US5470876A

  公开（公告）日：1995-11-28
• US6485950B1
  申请人：——

  公开号：US6485950B1

  公开（公告）日：2002-11-26
• US7037697B2
  申请人：——

  公开号：US7037697B2

  公开（公告）日：2006-05-02