4-Deoxy-D-glucuronic acid

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 4-Deoxy-D-glucuronic acid
• 英文别名: (2S,4S,5R,6R)-4,5,6-trihydroxyoxane-2-carboxylic acid
• 化学式: C₆H₁₀O₆
• 分子量: 178.14
• InChiKey: OGDYCNQXUUBOMI-RFPGKLGKSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.9
• 重原子数：
  12
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  107
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• A NEURAL SUBSTRATE FOR SUGAR PREFERENCE
  申请人：The Trustees of Columbia University in the City of New York

  公开号：EP3194416A1

  公开（公告）日：2017-07-26
• REGULATED BIOCIRCUIT SYSTEMS
  申请人：Obsidian Therapeutics, Inc.

  公开号：US20190192691A1

  公开（公告）日：2019-06-27

  The present invention provides regulatable biocircuit systems. Such systems provide modular and tunable protein expression systems in support of the discovery and development of therapeutic modalities.
• [EN] A NEURAL SUBSTRATE FOR SUGAR PREFERENCE<br/>[FR] SUBSTRAT NEURONAL DE PRÉFÉRENCE DE SUCRE
  申请人：UNIV COLUMBIA

  公开号：WO2016044756A1

  公开（公告）日：2016-03-24

  This invention concerns a composition and a method of modulating the craving and/or desire for natural sugar in a subject comprising: agonizing or stimulating or antagonizing or silencing a selective group of neurons in the cadual nucleus of the solitary tract (cNST) of the brain in the subject, wither directly or via the gut or gut-brain axis.