2,2',2''-(1,7,13-Trioxa-4,10,16-triazacyclooctadecane-4,10,16-triyl)triacetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2,2',2''-(1,7,13-Trioxa-4,10,16-triazacyclooctadecane-4,10,16-triyl)triacetic acid
• 英文别名: 2-[10,16-bis(carboxymethyl)-1,7,13-trioxa-4,10,16-triazacyclooctadec-4-yl]acetic acid
• 化学式: C₁₈H₃₃N₃O₉
• 分子量: 435.5
• InChiKey: HQMSLMXYNLKBAL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -8.4
• 重原子数：
  30
• 可旋转键数：
  6
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  149
• 氢给体数：
  3
• 氢受体数：
  12

文献信息

• Chelating agents with lipophilic carriers
  申请人：——

  公开号：US20040248856A1

  公开（公告）日：2004-12-09

  Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components.

  有用于与纳米粒子或微粒子乳液结合以获得磁共振图像的化合物，可以控制信号的弛豫度，并且可以轻松地与颗粒组分结合。
• Chelating agent derivatives and compositions comprising the same for use in imaging methods
  申请人：Koninklijke Philips Electronics N.V.

  公开号：EP2067490A1

  公开（公告）日：2009-06-10

  Chelating agent derivatives and methods to produce and use them are disclosed. The chelating agent derivatives comprise one or more chelating moieties attached either directly or via a linker to a phospholipid moiety. The chelating agent derivatives of the present invention are suitable to be incorporated in a great number of copies into a lipophilic nanoparticle or microparticle. They are advantageously used in imaging methods such as e.g. MRI.

  本发明公开了螯合剂衍生物及其制备和使用方法。螯合剂衍生物包括一个或多个螯合基团，直接或通过链接基团连接到磷脂基团上。本发明的螯合剂衍生物适合被并入到脂质纳米粒子或微粒中。它们可以优势地用于成像方法，例如MRI。
• Paramagnetic particles that provide improved relaxivity
  申请人：——

  公开号：US20030185760A1

  公开（公告）日：2003-10-02

  An improved contrast agent for magnetic resonance imaging comprises particles to each of which is coupled a multiplicity of chelating agents containing paramagnetic ions. In the improved agent, the position of the ion is offset from the surface of the particle so as to improve the relaxivity imparted by the contrast agent.

  一种用于磁共振成像的改进型造影剂由颗粒组成，每个颗粒上都耦合了多种含有顺磁离子的螯合剂。在改进型造影剂中，离子的位置偏离颗粒表面，以提高造影剂的弛豫性。
• Lipophilic derivatives of chelate monoamides
  申请人：Riley Patrick Dennis

  公开号：US20060008417A1

  公开（公告）日：2006-01-12

  Compounds useful for associating with nanoparticle or microparticle emulsions to obtain magnetic resonance images permit control of the relaxivity of the signal and readily associate with the particulate components. The compounds are conveniently prepared from achiral derivatives of chelating moieties.

  用于与纳米颗粒或微颗粒乳剂结合以获得磁共振图像的化合物可以控制信号的弛豫性，并易于与颗粒成分结合。这些化合物可方便地从螯合基团的非手性衍生物中制备。
• Efficacy and Safety of Targeted Particulate Agents with Decoy Systems
  申请人：Lanza Gregory M.

  公开号：US20080193372A1

  公开（公告）日：2008-08-14

  A decoy inactive carrier composition is administered simultaneously with a targeted composition containing vehicles for delivering a desired agent to a biological target. This simultaneous administration enhances the delivery of the targeted composition to the desired location in a subject.