Saquinavir/Nelfinavir deriv. 11

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Saquinavir/Nelfinavir deriv. 11
• 英文别名: (3S,4aS,8aS)-N-tert-butyl-2-[(2R,3S)-3-[[(2S)-3-(4-fluorophenyl)sulfinyl-2-(methanesulfonamido)propanoyl]amino]-2-hydroxy-4-phenylbutyl]-3,4,4a,5,6,7,8,8a-octahydro-1H-isoquinoline-3-carboxamide
• 化学式: C₃₄H₄₉FN₄O₆S₂
• 分子量: 692.9
• InChiKey: WXOMYWCKSSDBHF-OTSXENPMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  47
• 可旋转键数：
  14
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  173
• 氢给体数：
  4
• 氢受体数：
  10

文献信息

• Methods of treating cancer
  申请人：Potter A. David

  公开号：US20070009593A1

  公开（公告）日：2007-01-11

  Methods for treating cancer are described herein. The methods include administering to an HIV-negative patient an m-calpain inhibitor such as ritonavir. Ritonavir or other m-calpain inhibitors can also be co-administered with other therapeutic agents such as a Cox-2 inhibitor, a taxane, or a proteasome inhibitor. Methods for determining whether a patient will respond to a particular method of treatment are also described herein.