(+/-)-5-(4'-methoxyphenethyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: (+/-)-5-(4'-methoxyphenethyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
• 英文别名: 5-[2-(4-methoxyphenyl)ethyl]-2-methyl-3,4,5,6,7,8-hexahydro-1H-isoquinoline
• 化学式: C₁₉H₂₇NO
• 分子量: 285.429
• InChiKey: KLFJHQDQLINWEE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.7
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.58
• 拓扑面积：
  12.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  5-[2-(4-Methoxy-phenyl)-ethyl]-2-methyl-5,6,7,8-tetrahydro-isoquinolinium; iodide 在 sodium tetrahydroborate 作用下， 以 乙醇 为溶剂， 以74%的产率得到(+/-)-5-(4'-methoxyphenethyl)-2-methyl-1,2,3,4,5,6,7,8-octahydroisoquinoline
  参考文献：
  名称：

  Synthesis and antifungal activity of novel aza-d--homosteroids, hydroisoquinolines, pyridines and dihydropyridines

  摘要：

  A series of novel aza-D-homosteroids and their hydroisoquinoline precursors were synthesized and tested for antifungal activity against a variety of Candida strains and also Aspergillus species. A number of 4-substituted pyridines and tetrahydropyridines were also tested. Several compounds showed a broad spectrum of modest antifungal activity and three structures were investigated further for fungicidal and in vivo activity.

  DOI：

  10.1016/0223-5234(96)89557-2

文献信息

• Synthesis and antifungal activity of novel aza-d--homosteroids, hydroisoquinolines, pyridines and dihydropyridines
  作者：GL Patrick、OS Kinsman

  DOI：10.1016/0223-5234(96)89557-2

  日期：1996.1

  A series of novel aza-D-homosteroids and their hydroisoquinoline precursors were synthesized and tested for antifungal activity against a variety of Candida strains and also Aspergillus species. A number of 4-substituted pyridines and tetrahydropyridines were also tested. Several compounds showed a broad spectrum of modest antifungal activity and three structures were investigated further for fungicidal and in vivo activity.