1-[2-[3-[5-Chloro-1-(4-fluorophenyl)indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯
• 英文名称: 1-[2-[3-[5-Chloro-1-(4-fluorophenyl)indol-3-yl]-1-piperidyl]ethyl]imidazolidin-2-one
• 英文别名: 1-[2-[3-[5-chloro-1-(4-fluorophenyl)indol-3-yl]piperidin-1-yl]ethyl]imidazolidin-2-one
• 化学式: C₂₄H₂₆ClFN₄O
• 分子量: 440.9
• InChiKey: RZKJENYHFDICNB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.1
• 重原子数：
  31
• 可旋转键数：
  5
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  40.5
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• Use of Benzo-Heteroaryl Sulfamide Derivatives for the Treatment of Mania and Bipolar Disorder
  申请人：Smith-Swintosky Virginia L.

  公开号：US20070191450A1

  公开（公告）日：2007-08-16

  The present invention is a method for the treatment of mania and/or bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-heteroaryl sulfamide derivatives of formula (I) as herein defined.

  本发明是一种治疗躁狂症和/或双相情感障碍的方法，包括向需要的受试者施用一种或多种新型苯并杂环磺酰胺衍生物的治疗有效量，其化学式如下所定义。
• USE OF BENZO-FUSED HETEROCYLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MANIA AND BIPOLAR DISORDER
  申请人：Smith-Swintosky L. Virginia

  公开号：US20070155826A1

  公开（公告）日：2007-07-05

  The present invention is a method for the treatment of mania and/or bipolar disorder comprising administering to a subject in need thereof a therapeutically effective amount of one or more novel benzo-fused heterocycle sulfamide derivatives of formula (I) and formula (II) as herein defined.

  本发明涉及一种治疗躁狂症和/或双相情感障碍的方法，包括向需要的受试者施用根据本文所定义的一个或多个新型苯并杂环磺酰胺衍生物的治疗有效量，其化学式分别为(I)和(II)。
• Treatment of psychotic disorders comprising co-therapy with anticonvulsant derivatives and atypical antipsychotics
  申请人：——

  公开号：US20030109546A1

  公开（公告）日：2003-06-12

  Treatment of psychotic disorders such as schizophrenia, schizophreniform and schizoaffective disorders comprising co-therapy with an anticonvulsant derivative and a typical antipsychotic.

  治疗精神障碍，如精神分裂症、精神分裂症和情感分裂症，包括抗惊厥衍生物和典型抗精神病药物的联合治疗。
• TREATMENT OF PSYCHOTIC DISORDERS COMPRISING CO-THERAPY WITH ANTICONVULSANT DERIVATIVES AND ATYPICAL ANTIPSYCHOTICS
  申请人：Ortho-McNeil Pharmaceutical, Inc.

  公开号：EP1404342A1

  公开（公告）日：2004-04-07
• USE OF BENZO-FUSED HETEROCYCLE SULFAMIDE DERIVATIVES FOR THE TREATMENT OF MANIA AND BIPOLAR DISORDER
  申请人：Janssen Pharmaceutica N.V.

  公开号：EP1968573B1

  公开（公告）日：2011-03-16