(1R,2S)-2-[2-(5-aminopyrimidin-4-ylamino)cyclopentyl]ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (1R,2S)-2-[2-(5-aminopyrimidin-4-ylamino)cyclopentyl]ethanol
• 英文别名: 2-[(1R,2S)-2-[(5-aminopyrimidin-4-yl)amino]cyclopentyl]ethanol
• 化学式: C₁₁H₁₈N₄O
• 分子量: 222.29
• InChiKey: WHDMZEGQSUWYFP-SCZZXKLOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.64
• 拓扑面积：
  84.1
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (1S,2S)-2-[2-[bis(4-methoxyphenyl)-phenylmethoxy]ethyl]cyclopent-3-en-1-amine 在 palladium on activated charcoal 氢气 、 三乙胺 、 三氟乙酸 作用下， 以 甲醇 、 二氯甲烷 为溶剂， -20.0 ℃ 、172.37 kPa 条件下， 反应 9.0h， 生成 (1R,2S)-2-[2-(5-aminopyrimidin-4-ylamino)cyclopentyl]ethanol
  参考文献：
  名称：

  Synthesis of enantiomerically pure carbocyclic α-l-isomeric homonucleosides

  摘要：

  Synthesis of hitherto unknown carbocyclic alpha-L-isomeric homonucleosides (8a-b, 9a-b) is described. The key intermediate 6 was synthesized from the known compound I as a chiral starting material. Construction of the heterocyclic moiety around the amino group of 6 afforded carbocyclic alpha-L-isomeric 2',3'-dideoxyhomanucleosides 8a-b and their 2',3'-didehydro-2',3'-dideoxy derivatives 9a-b. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0040-4020(98)00471-2

文献信息

• Synthesis of enantiomerically pure carbocyclic α-l-isomeric homonucleosides
  作者：F. Girard、C. Demaison、M.-G. Lee、L.A. Agrofoglio

  DOI：10.1016/s0040-4020(98)00471-2

  日期：1998.7

  Synthesis of hitherto unknown carbocyclic alpha-L-isomeric homonucleosides (8a-b, 9a-b) is described. The key intermediate 6 was synthesized from the known compound I as a chiral starting material. Construction of the heterocyclic moiety around the amino group of 6 afforded carbocyclic alpha-L-isomeric 2',3'-dideoxyhomanucleosides 8a-b and their 2',3'-didehydro-2',3'-dideoxy derivatives 9a-b. (C) 1998 Elsevier Science Ltd. All rights reserved.