1-(2-Phenoxyethyl)-3-(2-pyridyl)thiourea

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1-(2-Phenoxyethyl)-3-(2-pyridyl)thiourea
• 英文别名: 1-(2-phenoxyethyl)-3-pyridin-2-ylthiourea
• 化学式: C₁₄H₁₅N₃OS
• 分子量: 273.36
• InChiKey: RFROJUPYUFWVPT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.7
• 重原子数：
  19
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  47.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• Piperidinylethyl-, phenoxyethyl-, and beta-fluorophenethyl-substituted thiourea compounds with potent anti-HIV activity
  申请人：——

  公开号：US20020151568A1

  公开（公告）日：2002-10-17

  The present invention is directed to derivatives of piperidinylethyl, phenoxyethyl, and fluorophenethyl bromopyridyl thioureas, which have been found to be effective non-nucleoside inhibitors (NNRTI) of NNI-resistant and multi-drug resistant human immunodeficiency virus (HIV)-1 reverse transcriptase (RT). The present invention is further directed to methods of using the above derivatives to treat patients with NNI-resistant or multi-drug resistant human immunodeficiency virus (HIV)-1.

  本发明涉及哌啶乙基、苯氧乙基和氟苯乙基溴吡啶硫脲类衍生物，已发现它们是对 NNI 耐药和对多种药物耐药的人类免疫缺陷病毒（HIV）-1 逆转录酶（RT）有效的非核苷抑制剂（NNRTI）。本发明进一步涉及使用上述衍生物治疗耐 NNI 或耐多药人类免疫缺陷病毒（HIV）-1 患者的方法。
• Phenoxyethyl-thiourea-pyridine compounds and their use for treatment of HIV-infections
  申请人：Parker Hughes Institute

  公开号：US20030186991A1

  公开（公告）日：2003-10-02

  The invention provides compounds which inhibit reverse transcriptase (RT) and which inhibit replication of a retrovirus, such as human immunodeficiency virus-1 (HIV-1). The compound of the invention are phenoxyethyl-thiourea-pyridines. The invention additionally provides a method for inhibiting reverse transcriptase activity of a retrovirus, such as HIV-1, comprising contacting the retrovirus with a compound of the invention. The invention additionally provides a method for inhibiting replication of a retrovirus, such as HIV-1, comprising contacting the retrovirus with a compound of the invention.

  本发明提供了抑制逆转录酶（RT）和抑制逆转录病毒（如人类免疫缺陷病毒-1（HIV-1））复制的化合物。本发明的化合物是苯氧乙基硫脲吡啶。本发明还提供了一种抑制逆转录病毒（如 HIV-1）逆转录酶活性的方法，包括将逆转录病毒与本发明化合物接触。本发明还提供了一种抑制逆转录病毒（如HIV-1）复制的方法，包括使逆转录病毒与本发明的化合物接触。
• US6727265B2
  申请人：——

  公开号：US6727265B2

  公开（公告）日：2004-04-27
• US6689793B2
  申请人：——

  公开号：US6689793B2

  公开（公告）日：2004-02-10