5-(8-hydroxyundecyl)benzene-1,3-diol

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 5-(8-hydroxyundecyl)benzene-1,3-diol
• 化学式: C₁₇H₂₈O₃
• 分子量: 280.408
• InChiKey: XABSZERNXXXRQK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  60.7
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  integracin A 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 生成 5-(8-hydroxyundecyl)benzene-1,3-diol
  参考文献：
  名称：

  Discovery, structure and HIV-1 integrase inhibitory activities of integracins, novel dimeric alkyl aromatics from Cytonaema sp.

  摘要：

  Integrase is a critical viral enzyme for HIV-1 replication and is a novel target for therapeutic intervention against HIV infections. Integracins A-C are three novel dimeric alkyl aromatic inhibitors of HIV-1 integrase discovered from the screening of fungal extracts using,in in vitro assay. These compounds inhibit both coupled and strand transfer activity of HIV-1 integrase with IC50 values of 3.2-6.1 and 17-88 muM, respectively. The discovery, structure and activity of these compounds are described. (C) 2002 Published by Elsevier Science Ltd.

  DOI：

  10.1016/s0040-4039(02)00083-7

文献信息

• Phosphonate Analogs Of Hiv Integrase Inhibitor Compounds
  申请人：Cai R. Zhenhong

  公开号：US20080076738A1

  公开（公告）日：2008-03-27

  Novel HIV integrase inhibitor compounds having at least one phosphonate group, protected intermediates thereof, and methods for inhibition of HIV-integrase are disclosed.

  本发明公开了至少具有一个膦酸酯基团的新型HIV整合酶抑制剂化合物、其受保护的中间体以及用于抑制HIV整合酶的方法。