H2N-Csvtcg-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H2N-Csvtcg-OH
• 英文别名: 2-[[(2R)-2-[[(2S,3R)-2-[[(2S)-2-[[(2S)-2-[[(2R)-2-amino-3-sulfanylpropanoyl]amino]-3-hydroxypropanoyl]amino]-3-methylbutanoyl]amino]-3-hydroxybutanoyl]amino]-3-sulfanylpropanoyl]amino]acetic acid
• 化学式: C₂₀H₃₆N₆O₉S₂
• 分子量: 568.7
• InChiKey: NXYZRFARQZTBAL-YLHZTVIJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -5.5
• 重原子数：
  37
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.7
• 拓扑面积：
  251
• 氢给体数：
  11
• 氢受体数：
  12

文献信息

• US6964763B1
  申请人：——

  公开号：US6964763B1

  公开（公告）日：2005-11-15
• [EN] METHODS AND COMPOSITIONS FOR INHIBITING HIV INFECTIVITY AND BLOCKING CHEMOKINE ACTIVITY<br/>[FR] COMPOSITIONS INHIBANT L'INFECTIOSITE DU VIRUS VIH ET ENTRAVANT L'ACTIVITE DE LA CHEMOKINE ET METHODES AFFERENTES
  申请人：CORNELL RES FOUNDATION INC

  公开号：WO1999026649A1

  公开（公告）日：1999-06-03

  The present invention relates to a method for suppressing infectivity of HIV which includes contacting the HIV or a cell targeted by HIV with an effective amount of a thrombospondin or a thrombospondin analog. Other aspects of the invention relate to contraceptives, pharmaceutical compositions, and non-contraceptive prophylactic devices that include a carrier and a thrombospondin or a thrombospondin analog. Methods of inhibiting HIV infection in a patient, blocking HIV binding to a cell, blocking chemokine binding to its receptor, and treating or preventing inflammatory states in a patient are also disclosed.