[(1,5-dimethyl-3-oxo-2-phenylpyrazolidin-4-yl)-methylazaniumyl]methanesulfonate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [(1,5-dimethyl-3-oxo-2-phenylpyrazolidin-4-yl)-methylazaniumyl]methanesulfonate
• 化学式: C13H19N3O4S
• 分子量: 313.37
• InChiKey: TVAQNNRGGZXZSK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.5
• 重原子数：
  21
• 可旋转键数：
  4
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  89.5
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• PHARMACEUTICAL COMBINATION
  申请人：Schiene Klaus

  公开号：US20090099138A1

  公开（公告）日：2009-04-16

  A combination comprising as components (a) the compound 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol, and (b) one or more non-steroidal anti-inflammatory drugs (NSAIDs); a pharmaceutical salt comprising said components; a compound derived from said components; a pharmaceutical formulation and a dosage form comprising said combination, salt, or compound; as well as a method of treating pain, e.g. chronic or acute pain, in a mammal characterized in that components (a) and (b) are administered simultaneously or sequentially to a mammal, wherein component (a) may be administered before or after component (b) and wherein components (a) or (b) are administered to the mammal either via the same or a different pathway of administration.

  一种组合物，包括以下成分：(a) 化合物3-(3-二甲基氨基-1-乙基-2-甲基-丙基)-苯酚，以及 (b) 一种或多种非甾体类抗炎药(NSAIDs)；包括上述成分的药物盐；由上述成分衍生的化合物；包括上述组合物、盐或化合物的药物制剂和剂型；以及一种治疗哺乳动物的疼痛，例如慢性或急性疼痛的方法，其特征在于将成分(a)和(b)同时或顺序给哺乳动物，其中成分(a)可以在成分(b)之前或之后给予，成分(a)或(b)可以通过相同或不同的给药途径给予哺乳动物。
• Pharmaceutical Combination
  申请人：GRUENENTHAL GmbH

  公开号：US20130190333A1

  公开（公告）日：2013-07-25

  A combination comprising as components (a) the compound 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol, and (b) one or more non-steroidal anti-inflammatory drugs (NSAIDs); a pharmaceutical salt comprising said components; a compound derived from said components; a pharmaceutical formulation and a dosage form comprising said combination, salt, or compound; as well as a method of treating pain, e.g. chronic or acute pain, in a mammal characterized in that components (a) and (b) are administered simultaneously or sequentially to a mammal, wherein component (a) may be administered before or after component (b) and wherein components (a) or (b) are administered to the mammal either via the same or a different pathway of administration.

  一种组合物，包括以下成分：(a) 化合物3-(3-二甲基氨基-1-乙基-2-甲基丙基)-苯酚，以及(b) 一种或多种非甾体抗炎药(NSAIDs)；包括上述成分的药物盐；由上述成分衍生的化合物；包括上述组合物、盐或化合物的制药配方和剂型；以及一种治疗哺乳动物疼痛的方法，例如慢性或急性疼痛，其特征在于将成分(a)和(b)同时或顺序给哺乳动物，其中成分(a)可以在成分(b)之前或之后给予，成分(a)或(b)可以通过相同或不同的给药途径给予哺乳动物。
• PHARMACEUTICAL COMBINATION COMPRISING 3- (3-DIMETHYLAMIN0-1-ETHYL-2-METHYL-PR0PYL) -PHENOL AND AN NSAID
  申请人：Grünenthal GmbH

  公开号：EP2012763A1

  公开（公告）日：2009-01-14
• [EN] PHARMACEUTICAL COMBINATION COMPRISING 3- (3-DIMETHYLAMIN0-1-ETHYL-2-METHYL-PR0PYL) -PHENOL AND AN NSAID<br/>[FR] COMBINAISON PHARMACEUTIQUE COMPRENANT 3- (3-DIMÉTHYLAMINO-1-ÉTHYL-2-MÉTHYL-PROPYL) -PHÉNOL et UN AINS
  申请人：GRUENENTHAL GMBH

  公开号：WO2007128412A1

  公开（公告）日：2007-11-15

  [EN] The present invention relates to a combination comprising as components (a) the compound 3-(3-Dimethylamino-1-ethyl-2-methyl-propyl)-phenol, and (b) one or more non-steroidal anti-inflammatory drugs (NSAIDs); a pharmaceutical salt comprising said components; a compound derived from said components; a pharmaceutical formulation and a dosage form comprising said combination, salt, or compound; as well as a method of treating pain, e.g. chronic or acute pain, in a mammal characterized in that components (a) and (b) are administered simultaneously or sequentially to a mammal, wherein component (a) may be administered before or after component (b) and wherein components (a) or (b) are administered to the mammal either via the same or a different pathway of administration.
  [FR] La présente invention concerne la combinaison dont les éléments sont (a) le composé -(3-Diméthylamino-1-éthyl-2-méthyl-propyl)-phénol, et le composé (b) comprenant au moins un médicament anti-inflammatoire non stéroïdien (AINS); un sel pharmaceutique comprenant lesdits composants; un composé dérivé desdits composants; une préparation pharmaceutique et une forme posologique comprenant la dite combinaison, ledit sel ou composé; ainsi qu'une méthode de traitement de la douleur, par exemple, d'une douleur chronique ou violente chez un mammifère en tenant compte du fait que les composants (a) et (b) sont administrés de manière simultanée ou consécutive au mammifère, le composant (a) pouvant être administré avant ou après le composant (b) et ces composants (a) et (b) étant administrés au mammifère soit par la même voie soit par une voie différente.