2-[[2-(2-Pyridylmethylsulfanyl)benzimidazol-1-yl]methoxy]ethanol

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: 2-[[2-(2-Pyridylmethylsulfanyl)benzimidazol-1-yl]methoxy]ethanol
• 英文别名: 2-[[2-(pyridin-2-ylmethylsulfanyl)benzimidazol-1-yl]methoxy]ethanol
• 化学式: C₁₆H₁₇N₃O₂S
• 分子量: 315.396
• InChiKey: MYAGSCXUKZHFOH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  22
• 可旋转键数：
  7
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  85.5
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  2-{[(pyridin-2-yl)methyl]thio}-1H-benzimidazole 在 sodium hydride 、 sodium carbonate 作用下， 以 乙醇 、 乙腈 为溶剂， 反应 21.5h， 生成 2-[[2-(2-Pyridylmethylsulfanyl)benzimidazol-1-yl]methoxy]ethanol
  参考文献：
  名称：

  Synthesis and antiviral assays of some benzimidazole nucleosides and acyclonucleosides

  摘要：

  Some benzimidazole nucleosides and acyclonucleosides were synthesized and tested in vitro as antiviral agents. None of them showed significant activity. Replacement of the benzenesulphonyl group at N-1 with the ribofuranosyl moiety or with the acyclovir side-chain was deleterious. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01164-8

文献信息

• Synthesis and antiviral assays of some benzimidazole nucleosides and acyclonucleosides
  作者：Laura Garuti、Marinella Roberti、Giovanna Gentilomi

  DOI：10.1016/s0014-827x(01)01164-8

  日期：2001.11

  Some benzimidazole nucleosides and acyclonucleosides were synthesized and tested in vitro as antiviral agents. None of them showed significant activity. Replacement of the benzenesulphonyl group at N-1 with the ribofuranosyl moiety or with the acyclovir side-chain was deleterious. (C) 2001 Elsevier Science S.A. All rights reserved.