1-(2-carboxyethyl)cyclopropanecarboxylic acid | 33229-05-9

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 1-(2-carboxyethyl)cyclopropanecarboxylic acid
• 英文别名: 3-(1-Carboxy-cyclopropyl)-propionsaeure；3-(1-carboxy-cyclopropyl)-propionic acid；Cyclopropan-carbonsaeure-(1)-(β-propionsaeure)-(1)；1-(2-Carboxyethyl)cyclopropane-1-carboxylic acid；1-(2-carboxyethyl)cyclopropane-1-carboxylic acid
• CAS: 33229-05-9
• 化学式: C₇H₁₀O₄
• 分子量: 158.154
• InChiKey: GTBYMPZBNKSEOW-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.1
• 重原子数：
  11
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  2,2-dimethyl-4-methoxycarbonylbutanoyl chloride 在 palladium diacetate 碘苯二乙酸 、 硫酸 、 碘 、 三苯基膦 、 过氧化苯甲酰 作用下， 以 1,4-二氧六环 、 乙酸乙酯 、 苯 为溶剂， 反应 65.0h， 生成 1-(2-carboxyethyl)cyclopropanecarboxylic acid
  参考文献：
  名称：

  Converting gem-Dimethyl Groups into Cyclopropanes via Pd-Catalyzed Sequential C−H Activation and Radical Cyclization

  摘要：

  A novel route to the synthesis of cyclopropane derivatives is described. 1,1-Dimethyls in 2-(1,1-dimethylalkyl)dimethyloxazolines are first converted into 1,3-diiodide derivatives via Pd-catalyzed sequential C-H activation and then radically cyclized to provide 2-(1-alkylcylclopropyl)dimethyloxazolines. The use of EtOAc as a solvent is crucial for the diiodination of the functionalized substrates.

  DOI：

  10.1021/ol0618858

文献信息

• [EN] MULTI- API LOADING PRODRUGS<br/>[FR] PROMÉDICAMENTS CHARGÉS DE MULTIPLES PRINCIPES ACTIFS
  申请人：ALKERMES INC

  公开号：WO2012088441A1

  公开（公告）日：2012-06-28

  The present invention accomplishes this by having multiple molecules of parent drugs attached to carrier moieties and by extending the period during which the parent drug is released and absorbed after administration to the patient and providing a longer duration of action per dose than the parent drug itself. Prodrug conjugates are suitable for sustained delivery of heteroaryl, lactam- amide-, imide-, sulfonamide-, carbamate-, urea-, benzamide-, acylaniline-, cyclic amide- and tertiary amine-containing parent drugs that are substituted at the amide nitrogen or oxygen atom with labile aldehyde-linked prodrug moieties. The carrier groups of the prodrugs can be hydrophobic to reduce the polarity and solubility of the parent drug under physiological conditions.

  本发明通过将多个母药分子附着在载体基团上，并延长母药在患者服用后释放和吸收的时间，从而实现此目的，并提供每剂次比母药本身更长的作用时间。前药偶联物适用于异杂环、内酰胺、酰胺、磺酰胺、氨基甲酸酯、脲、苯甲酰胺、酰基苯胺、环状酰胺和三级胺含有母药，该母药在酰胺氮或氧原子处以不稳定的醛类前药基团取代。前药的载体基团可以是疏水性的，在生理条件下降低母药的极性和溶解度。
• COMPOSITE STRUCTURED ORGANIC FILMS
  申请人：HEUFT Matthew A.

  公开号：US20100227157A1

  公开（公告）日：2010-09-09

  A structured organic film with an added functionality comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein the structured organic film may be a multi-segment thick structured organic film.

  一种具有附加功能的有序有机薄膜，包括多个片段和多个连接剂，排列成共价有机框架，其中有序有机薄膜可以是多片段厚有序有机薄膜。
• ELECTRONIC DEVICES COMPRISING STRUCTURED ORGANIC FILMS
  申请人：HEUFT Matthew A.

  公开号：US20100224867A1

  公开（公告）日：2010-09-09

  An electronic device comprising a structured organic film with an added functionality comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein the structured organic film may be a multi-segment thick structured organic film.

  一种电子设备，包括一种有附加功能的结构有机膜，其中该结构有机膜由多个分段和多个连接体排列组成，形成一个共价有机框架，该结构有机膜可以是多分段厚结构有机膜。
• STRUCTURED ORGANIC FILMS HAVING AN ADDED FUNCTIONALITY
  申请人：COTE Adrien Pierre

  公开号：US20100228025A1

  公开（公告）日：2010-09-09

  A structured organic film with an added functionality comprising a plurality of segments and a plurality of linkers arranged as a covalent organic framework, wherein the structured organic film may be a multi-segment thick structured organic film.

  一种具有附加功能的结构有机膜，由多个片段和多个连接物排列成共价有机框架，其中结构有机膜可以是多片段厚的结构有机膜。
• Toner preparation processes
  申请人：Xerox Corporation

  公开号：EP1752830A1

  公开（公告）日：2007-02-14

  A method of making toner particles, includes: mixing a latex emulsion, a colorant emulsion, an optional wax emulsion, and optional additives in a first reactor to form a slurry; discharging the slurry from the first reactor to a second reactor through a homogenizer; heating the slurry in the second reactor to form aggregated particles in said slurry; discharging the aggregated particles and slurry from the second reactor to a third reactor; heating the aggregated particles and slurry in the third reactor to coalesce the aggregated particles into toner particles; discharging the toner particles and slurry from the third reactor to a fourth reactor; cooling the toner particles; optionally classifying said toner particles to remove coarse particles; and optionally washing and drying said toner particles, wherein the first reactor, second reactor, third reactor, and fourth reactor are at least two different reactors.

  一种制造墨粉颗粒的方法，包括在第一反应器中混合乳胶乳液、着色剂乳液、任选蜡乳液和任选添加剂以形成浆料；通过均化器将浆料从第一反应器排放到第二反应器；在第二反应器中加热浆料以在所述浆料中形成聚集颗粒；将聚集颗粒和浆料从第二反应器排放到第三反应器；在第三反应器中加热聚集颗粒和浆料，使聚集颗粒凝聚成墨粉颗粒；将墨粉颗粒和浆料从第三反应器排放到第四反应器；冷却墨粉颗粒；选择性地对所述墨粉颗粒进行分级以去除粗颗粒；以及选择性地洗涤和干燥所述墨粉颗粒，其中第一反应器、第二反应器、第三反应器和第四反应器是至少两个不同的反应器。