Histidine-

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Histidine-
• 英文别名: 2-amino-3-(1H-imidazol-5-yl)propanoic acid;copper
• 化学式: C6H9CuN3O2
• 分子量: 218.7
• InChiKey: UXMNQKKPBFTHMU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.64
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  92
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• COMPOUND AND COMPOSITION AND THEIR USES THEREOF
  申请人：KANDULA MAHESH

  公开号：US20110218235A1

  公开（公告）日：2011-09-08

  A compound, composition, method of synthesizing and using the compound of formula 1 are disclosed. The compound of formula I also comprises of salts, polymorphs, solvates, and hydrates thereof. The compound may be formulated as pharmaceutical compositions. The pharmaceutical compositions may be formulated for peroral, topical, transmucosal, inhalation, targeted delivery and sustained release formulations. Such compositions may be used to treat hepatic and genetic disorders related to copper overload.

  揭示了一种化合物、组合物、合成和使用公式1的方法。公式I的化合物还包括其盐、多型体、溶剂合物和水合物。该化合物可以制成药物组合物。药物组合物可以制成口服、局部、经粘膜、吸入、靶向递送和缓释制剂。这些组合物可用于治疗与铜超载相关的肝脏和遗传疾病。
• [EN] A PROCESS FOR THE PRODUCTION OF OXIDIZED WOOD PRODUCTS<br/>[FR] PROCÉDÉ DE PRODUCTION DE PRODUITS LIGNEUX OXYDÉS
  申请人：ORGANOFUEL SWEDEN AB

  公开号：WO2020156857A1

  公开（公告）日：2020-08-06

  The present invention relates to a process for the production of oxidized wood products, comprising step a) reacting chips of one or more wood products in a basic solution at a p H between 8 and 14 under an oxygen atmosphere at a pressure of at least 0.1 MPa, or at least 0.9 MPa. A copper catalyst may be used in the process.

  本发明涉及一种生产氧化木制品的方法，包括步骤a）在pH值在8到14之间的碱性溶液中，在至少0.1 MPa或至少0.9 MPa的氧气氛压力下反应一种或多种木制品的木片。在该过程中可以使用铜催化剂。
• Novel dermatological composition
  申请人：EBERSYTES, LLC

  公开号：US20040247633A1

  公开（公告）日：2004-12-09

  The invention provides novel dermatological compositions and related methods useful in the activation of skin growth factors and growth receptors. Compositions of the invention act upon follicle cells and other skin targets to induce hair growth, facilitate dermal cell repair, and enhance skin health.

  本发明提供了新型皮肤学组合物和相关方法，用于激活皮肤生长因子和生长受体。本发明的组合物作用于毛囊细胞和其他皮肤靶标，诱导发际生长，促进真皮细胞修复和增强皮肤健康。
• Codon-optimized reduced-size ATP7A cDNA and uses for treatment of copper transport disorders
  申请人：The United States of America, as represented by the Secretary, Dept. of Health and Human Services

  公开号：US10988778B2

  公开（公告）日：2021-04-27

  Disclosed herein are codon-optimized nucleic acids encoding a reduced-size ATP7A protein. Also disclosed are vectors and recombinant viruses (such as recombinant adeno-associated viruses) including the codon-optimized nucleic acids encoding the reduced-size ATP7A protein and compositions including the disclosed vectors and viruses. Further disclosed herein are methods of treating copper transport disorders, for example by administering a disclosed nucleic acid, vector, or recombinant virus to a subject with a copper transport disorder, such as Menkes disease, occipital horn syndrome, or ATP7A-related distal motor neuropathy.

  本文公开了编码缩小尺寸 ATP7A 蛋白的密码子优化核酸。还公开了包括编码缩小尺寸 ATP7A 蛋白的密码子优化核酸的载体和重组病毒（如重组腺相关病毒）以及包括所公开载体和病毒的组合物。本文进一步公开了治疗铜转运障碍的方法，例如通过给患有铜转运障碍的受试者施用所公开的核酸、载体或重组病毒，如梅克斯病、枕角综合征或ATP7A相关的远端运动神经病。
• Wilson's disease gene therapy
  申请人：UCL Business Ltd

  公开号：US11077208B2

  公开（公告）日：2021-08-03

  There is described a new gene therapy approach for treating Wilson's disease in which a nucleic acid molecule is used which comprises a nucleotide sequence encoding for a functional ATP7B protein wherein the nucleotide sequence has at least 85% identity to the sequence of SEQ ID NO: 1. Also described are vectors comprising the nucleotide sequence and methods and uses thereof.

  描述了一种治疗威尔森氏病的新基因治疗方法，其中使用了一种核酸分子，该核酸分子包含编码功能性 ATP7B 蛋白的核苷酸序列，其中核苷酸序列与 SEQ ID NO: 1 的序列至少有 85% 的同一性。还描述了包含该核苷酸序列的载体及其方法和用途。