3β-Hydroxyandrosta-5,7-dien | 6788-19-8

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 类固醇和类固醇衍生物
• 英文名称: 3β-Hydroxyandrosta-5,7-dien
• 英文别名: Androsta-5,7-dien-3β-ol；androstadien-(5,7)-ol-(3β)；3β-Hydroxy-10.13-dimethyl-gonadien-(5.7)；(10R)-3c-Hydroxy-10r.13c-dimethyl-(9tH.14tH)-Δ^5.7-dodecahydro-1H-cyclopenta[a]phenanthren；(3S,9S,10R,13S,14R)-10,13-dimethyl-2,3,4,9,11,12,14,15,16,17-decahydro-1H-cyclopenta[a]phenanthren-3-ol
• CAS: 6788-19-8
• 化学式: C₁₉H₂₈O
• 分子量: 272.431
• InChiKey: IDMUJCWCVWMQEH-GBBGEASQSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  20
• 可旋转键数：
  0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  20.2
• 氢给体数：
  1
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  3β-Hydroxyandrosta-5,7-dien 在 镍 氢气 作用下， 生成 5α-androst-7-ene
  参考文献：
  名称：

  Mass spectrometry in structural and stereochemical problems. 248. Stereochemical effects in electron impact induced retro-Diels-Alder fragmentations

  摘要：

  DOI：

  10.1021/ja00452a041
• 作为产物：
  描述：

  雄甾-5-烯-3-醇 在 四氯化碳 、 N-溴代丁二酰亚胺(NBS) 作用下， 生成 3β-Hydroxyandrosta-5,7-dien
  参考文献：
  名称：

  de Vries; Backer, Recueil des Travaux Chimiques des Pays-Bas, 1952, vol. 71, p. 719,724

  摘要：

  DOI：

文献信息

• Novel method for the preparation of intermediates useful for the synthesis fo vitamin d analogues
  申请人：Hansen Torngaard Erik

  公开号：US20070135395A1

  公开（公告）日：2007-06-14

  The present invention relates to novel methods for the preparation of intermediates which are useful in the synthesis of cacipotriol. The present invention relates further to the use of intermediates produced with said methods for making calcipotriol or calcipotriol monohydrate.

  本发明涉及一种新的方法，用于制备在合成卡西泊酯过程中有用的中间体。本发明进一步涉及使用采用上述方法制备的中间体来制备卡西泊酯或卡西泊酯一水合物。
• Enzymatic Production or Chemical Synthesis and Uses for 5,7-Dienes and UVB Conversion Products Thereof
  申请人：Slominski Andrej

  公开号：US20120258938A1

  公开（公告）日：2012-10-11

  Provided herein are steroidal compounds that are androsta-5,7-dienes or pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof and cholecalciferol derivatives hydroxylated at one or more of C1, C17, C20, C23, C24, C25, and C26 which includes pharmaceutical, cosmeceutical or nutraceutical compositions of the steroidal compounds as shown in Tables 1A, 2A and 3. Also provided is a method for producing hydroxylated metabolites of cholecalciferol via CYP11A1, CYP24, CYP27A1, or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C1 or C20 or other position of the sidechain of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. Methods are provided for inhibiting proliferation of either a normally or abnormally proliferating cell, for modifying immune activity, or for treating a condition associated with the proliferating or quiescent cell or immune cells by contacting the cell with or administering any of the compounds described herein.

  本文提供的是雄甾-5,7-二烯或孕甾-5,7-二烯及其紫外线B（UVB）转化产物和羟化在C1、C17、C20、C23、C24、C25和C26上的胆钙醇衍生物，其中包括表1A、2A和3中所示的雄甾类化合物的制药、化妆品或营养品组合物。同时，本文还提供了一种通过CYP11A1、CYP24、CYP27A1或CYP27B1酶系统产生羟化代谢产物的方法，其中羟化酶具有羟化分裂素或其5,7-二烯前体的侧链的C1或C20或其他位置的活性，以及由此产生的羟化代谢产物。本文还提供了一种通过接触或给予本文所述的任何化合物来抑制正常或异常增殖细胞的增殖，修饰免疫活性或治疗与增殖或静止细胞或免疫细胞相关的疾病的方法。
• Enzymatic production or chemical synthesis and uses for 5,7-dienes and UVB conversion products thereof
  申请人：Slominski Andrzej

  公开号：US20110118228A1

  公开（公告）日：2011-05-19

  Provided herein are steroidal compounds that are androsta-5,7-dienes or a pregna-5,7-dienes and ultraviolet B (UVB) conversion products thereof which includes pharmaceutical compositions of the steroidal compounds as shown in Tables 1 and 2. Also provided is a method for producing hydroxylated metabolites of cholecalciferol or ergocalciferol via the P450scc (CYP11A1) or CYP27B1 enzyme systems where the hydroxylase has an activity to hydroxylate position C20 of a secosteroid or its 5,7-dieneal precursor and the hydroxylated metabolites so produced. In addition, a method for inhibiting proliferation of either a normally or abnormally proliferating cell by contacting the cell with any of the compounds described herein. A related method is provided of treating a condition associated with the proliferating cell such as a cancer, a skin disorder, a defect in cell differentiation, cosmetic, prophylaxsis, or healthy cell maintenance.

  本文提供的是雄甾-5,7-二烯或孕甾-5,7-二烯及其紫外线B（UVB）转化产物的类固醇化合物，其中包括所示的表1和表2的类固醇化合物的药物组成。此外，还提供了一种通过P450scc（CYP11A1）或CYP27B1酶系统产生维生素D3或维生素D2的羟化代谢产物的方法，其中羟化酶具有羟化一个类固醇的C20位置或其5,7-二烯前体的活性，以及所产生的羟化代谢产物。此外，还提供了一种通过接触任何本文所述的化合物来抑制正常或异常增殖细胞增殖的方法。还提供了一种相关的方法，用于治疗与增殖细胞相关的疾病，例如癌症，皮肤疾病，细胞分化缺陷，美容，预防或维持健康的细胞。
• Studies in the Synthesis of the Antirachitic Vitamins. II. Δ⁵-Androstenol-3 and its Partial Dehydrogenation with Benzoquinone^1,2
  作者：Nicholas A. Milas、Charles R. Milone

  DOI：10.1021/ja01209a005

  日期：1946.5
• Mass spectrometry in structural and stereochemical problems. 248. Stereochemical effects in electron impact induced retro-Diels-Alder fragmentations
  作者：J. Scott Dixon、I. Midgley、Carl Djerassi

  DOI：10.1021/ja00452a041

  日期：1977.5