5-(Imidazol-1-yl-phenyl-methyl)-2-methyl-4-phenyl-pyrimidine

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 5-(Imidazol-1-yl-phenyl-methyl)-2-methyl-4-phenyl-pyrimidine
• 英文别名: 5-[Imidazol-1-yl(phenyl)methyl]-2-methyl-4-phenyl-pyrimidine；5-[imidazol-1-yl(phenyl)methyl]-2-methyl-4-phenylpyrimidine
• 化学式: C₂₁H₁₈N₄
• 分子量: 326.401
• InChiKey: ZCXXHGAIYMJVGO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.1
• 拓扑面积：
  43.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  (2-Methyl-4-phenyl-pyrimidin-5-yl)-phenyl-methanol 在 三溴化磷 、 三乙胺 作用下， 以 乙醚 、 氯仿 、 乙腈 为溶剂， 反应 28.0h， 生成 5-(Imidazol-1-yl-phenyl-methyl)-2-methyl-4-phenyl-pyrimidine
  参考文献：
  名称：

  Synthesis and biological evaluation of azole derivatives, analogues of bifonazole, with a phenylisoxazolyl or phenylpyrimidinyl moiety

  摘要：

  A series of azole derivatives, isoxazole or pyrimidine analogues of the antifungal drug bifonazole, were synthesized and tested in vitro against representative human pathogenic fungi (Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus). They were also evaluated as antibacterial agents against Staphylococcus aureus and Salmonella spp. Only 5-(imidazol-1-yl-phenylmethyl)-2,4-diphenyl-pyrimidine 7c showed weak antimicrobial activity (MIC = 66 muM) against C. albicans, C. neoformans and S. aureus. Results of biological tests proved, therefore, that replacement of the biphenyl portion of the bifonazole with a phenylisoxazolyl or phenylpyrimidinyl moiety is not profitable for antimicrobial properties. (C) 2001 Elsevier Science S.A. All rights reserved.

  DOI：

  10.1016/s0014-827x(01)01117-x

文献信息

• Synthesis and biological evaluation of azole derivatives, analogues of bifonazole, with a phenylisoxazolyl or phenylpyrimidinyl moiety
  作者：Giulia Menozzi、Luisa Mosti、Paola Fossa、Chiara Musiu、Chiara Murgioni、Paolo La Colla

  DOI：10.1016/s0014-827x(01)01117-x

  日期：2001.8

  A series of azole derivatives, isoxazole or pyrimidine analogues of the antifungal drug bifonazole, were synthesized and tested in vitro against representative human pathogenic fungi (Candida albicans, Cryptococcus neoformans and Aspergillus fumigatus). They were also evaluated as antibacterial agents against Staphylococcus aureus and Salmonella spp. Only 5-(imidazol-1-yl-phenylmethyl)-2,4-diphenyl-pyrimidine 7c showed weak antimicrobial activity (MIC = 66 muM) against C. albicans, C. neoformans and S. aureus. Results of biological tests proved, therefore, that replacement of the biphenyl portion of the bifonazole with a phenylisoxazolyl or phenylpyrimidinyl moiety is not profitable for antimicrobial properties. (C) 2001 Elsevier Science S.A. All rights reserved.