Acetic acid;cobalt

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Acetic acid;cobalt
• 化学式: C4H8CoO4
• 分子量: 179.04
• InChiKey: WOQRGAPCUQZBRA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.18
• 重原子数：
  9
• 可旋转键数：
  0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

ADMET

毒理性

• 毒性总结

识别和使用：醋酸钴是一种固体。它用作漆和清漆的漂白剂和干燥剂；在阳极氧化过程中；以及作为氧化和酯化的催化剂。牛饲料中的矿物质补充剂。人类暴露和毒性：急性人类暴露导致呕吐，上腹部剧痛和压痛，四肢疼痛伴有明显无力，呕血和便中潜血。在暴露于醋酸钴的照射HeLa细胞中，DNA链断裂累积并抑制修复。动物研究：通过胃管给大鼠给药后，急性效应包括镇静，腹泻和体温下降。大体病理检查显示肝脏，肾脏和心脏出血和营养不良变化。大鼠口服暴露导致血红蛋白和血细胞比容以及血浆蛋白的增加。出现了明显的血糖升高，以及血脂参数（如甘油三酯和胆固醇）的显著变化。在大鼠在轻度缺血条件下急性醋酸钴中毒后观察到神经学体征。据报道，它对仓鼠或大鼠没有致畸性。已经描述了氧化DNA碱基损伤。

IDENTIFICATION AND USE: Cobaltous acetate is a solid. It is used as a bleaching agent and drier for lacquers, varnishes; in anodizing; and as a catalyst for oxidation and esterification. Mineral supplement in cattle feed. HUMAN EXPOSURE AND TOXICITY: Acute human exposure led to vomiting, severe pain and tenderness in epigastrium, pain in limbs with marked weakness, hematemesis, and occult blood in stools. DNA strand breaks accumulated and repair was inhibited in irradiated HeLa cells exposed to cobaltous acetate. ANIMAL STUDIES: Following administration to rats by gastric intubation acute effects included sedation, diarrhea, and decreased body temperature. Gross pathology exam revealed hemorrhages and dystrophic changes in the liver, kidney, and heart. Oral exposure in rats led to increase in the hemoglobin and hematocrit as well as in the plasma proteins. There was significant hyperglycemia and also significant changes in the lipid parameters such as triglycerides and cholesterol. The neurological signs were observed in rats after acute cobaltous acetate intoxication under mild ischemic conditions. It was not reported to be teratogenic in hamsters or rats. Oxidative DNA base damage has been described.

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

...对于实验动物中钴(III)醋酸盐的致癌性证据不足。总体评估：钴和钴化合物可能对人类具有致癌性（2B组）。/钴和钴化合物/

... There is inadequate evidence for the carcinogenicity of ... cobalt(III) acetate in experimental animals. Overall Evaluation: Cobalt and cobalt compounds are possibly carcinogenic to humans (Group 2B). /Cobalt and cobalt compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

钴和钴化合物在人类中的致癌性证据不足。有充分证据表明钴金属粉末在实验动物中具有致癌性。有限证据显示含有钴、铬和钼的金属合金在实验动物中具有致癌性。总体评估：钴和钴化合物可能对人类具有致癌性（2B组）。/钴和钴化合物/

There is inadequate evidence for the carcinogenicity of cobalt and cobalt compounds in humans. There is sufficient evidence for the carcinogenicity of cobalt metal powder in experimental animals. There is limited evidence for the carcinogenicity of metal alloys containing cobalt, chromium and molybdenum in experimental animals. ... Overall Evaluation: Cobalt and cobalt compounds are possibly carcinogenic to humans (Group 2B). /Cobalt and cobalt compounds/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

A3：已确认的动物致癌物，对人类的相关性未知。/钴和钴的无机化合物/

A3: Confirmed animal carcinogen with unknown relevance to humans. /Cobalt and inorganic compounds, as Co/

来源:Hazardous Substances Data Bank (HSDB)

毒理性

• 致癌性证据

钴和释放钴离子的钴化合物根据实验动物研究中充分的致癌性证据以及对致癌机制研究的支持数据，可以合理地预期为人类致癌物。/钴和钴化合物/

Cobalt and cobalt compounds that release cobalt ions in vivo are reasonably anticipated to be human carcinogens based on sufficient evidence of carcinogenicity from studies in experimental animals and supporting data from studies on mechanisms of carcinogenesis. /Cobalt and cobalt compounds/

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

在大鼠中，从胃肠道（GI）的吸收率在11%到34%之间，具体取决于给药剂量。在肝脏中发现了最高的浓度，而在肾脏、胰腺和脾脏中记录到了较低的浓度。

Absorption from the GI tract in rats was found to vary between 11 and 34% depending on administered dose value. The highest concn was found in the liver, a low concn was noted in the kidney, pancreas, and spleen.

来源:Hazardous Substances Data Bank (HSDB)

吸收、分配和排泄

物质可以通过吸入其气溶胶和通过摄入被吸收进人体。/四水合物（这张卡片上的建议也适用于无水醋酸钴（II）（CAS 71-48-7）。）/

The substance can be absorbed into the body by inhalation of its aerosol and by ingestion. /Tetrahydrate ("The recommendations on this Card also apply to Cobalt (II) acetate anhydrous (CAS 71-48-7).")/

来源:Hazardous Substances Data Bank (HSDB)