N-(2-Hydroxy-butyl)-acetamid | 4293-58-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-(2-Hydroxy-butyl)-acetamid
• 英文别名: N-1-(2-Hydroxybutyl) acetamide；N-(2-hydroxybutyl)acetamide
• CAS: 4293-58-7
• 化学式: C₆H₁₃NO₂
• 分子量: 131.175
• InChiKey: LTKKVHOQYLMJFD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.2
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  49.3
• 氢给体数：
  2
• 氢受体数：
  2

文献信息

• MODULATORS OF ATP-BINDING CASSETTE TRANSPORTERS
  申请人：Vertex Pharmaceuticals Inc.

  公开号：EP3091011A1

  公开（公告）日：2016-11-09

  Compounds of the present invention and pharmaceutically acceptable compositions thereof, are useful as modulators of ATP-Binding Cassette ("ABC") transporters or fragments thereof, including Cystic Fibrosis Transmembrane Conductance Regulator ("CFTR"). The present invention also relates to methods of treating ABC transporter mediated diseases using compounds of the present invention.

  本发明的化合物及其药学上可接受的组合物可用作 ATP 结合盒（"ABC"）转运体或其片段（包括囊性纤维化跨膜传导调节器（"CFTR"））的调节剂。本发明还涉及使用本发明化合物治疗 ABC 转运体介导的疾病的方法。
• NUCLEIC ACID COMPLEX
  申请人：Kyowa Hakko Kirin Co., Ltd.

  公开号：EP3498724A1

  公开（公告）日：2019-06-19

  The present invention provides a nucleic acid conjugate in which a sugar chain ligand is bonded to an oligonucleotide via a linker, the sugar chain ligand having O-bonded mannose at its non-reducing end.

  本发明提供了一种核酸共轭物，其中糖链配体通过连接体与寡核苷酸结合，糖链配体的非还原端具有 O 键甘露糖。
• INDAZOLE DERIVATIVE, PREPARATION METHOD THEREFOR, AND PHARMACEUTICAL APPLICATION THEREOF
  申请人：Jiangsu Hengrui Medicine Co., Ltd.

  公开号：EP3988547A1

  公开（公告）日：2022-04-27

  An indazole derivative, a preparation method therefor, and a pharmaceutical application thereof. In particular, the present invention relates to an indazole derivative represented by general formula (I), a preparation method therefor, a pharmaceutical composition comprising the derivative, and a use of the derivative as an estrogen receptor modulator in the prevention and/or treatment of an estrogen receptor mediated or dependent disease or condition, the disease being particularly preferably breast cancer. The definition of each substituent in the general formula (I) is the same as that in the description.

  一种吲唑衍生物、其制备方法及其药物应用。具体而言，本发明涉及一种由通式（I）表示的吲唑衍生物、其制备方法、包含该衍生物的药物组合物，以及该衍生物作为雌激素受体调节剂在预防和/或治疗雌激素受体介导或依赖性疾病或病症中的用途，该疾病尤其优选乳腺癌。通式（I）中各取代基的定义与描述中的相同。
• PROTEASE INHIBITORS
  申请人：SmithKline Beecham Corporation

  公开号：EP1067894A2

  公开（公告）日：2001-01-17
• EP1067894A4
  申请人：——

  公开号：EP1067894A4

  公开（公告）日：2004-09-08

表征谱图