1,2,4-Trichloro-5-isopropoxybenzene

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 1,2,4-Trichloro-5-isopropoxybenzene
• 英文别名: 1,2,4-trichloro-5-propan-2-yloxybenzene
• 化学式: C₉H₉Cl₃O
• mdl: MFCD23114864
• 分子量: 239.5
• InChiKey: KRWAFSMISJEYKC-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.6
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.333
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• TROPANE DERIVATIVES USEFUL AS PESTICIDES
  申请人：Selles Patrice

  公开号：US20100331348A1

  公开（公告）日：2010-12-30

  Compounds of formula (I) wherein the substituents have the meanings assigned to them in claim 1, are useful as pesticides.

  式(I)中的化合物，其中取代基具有在权利要求书1中分配给它们的含义，可用作杀虫剂。
• Oligosaccharides comprising an aminooxy group and conjugates thereof
  申请人：Genzyme Corporation

  公开号：US10907142B2

  公开（公告）日：2021-02-02

  The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.

  本发明提供了包含氨基氧基的低聚糖的合成方法。本发明进一步提供了包含氨基氧基的低聚糖、将包含氨基氧基的低聚糖与糖蛋白偶联的方法，以及低聚糖-蛋白共轭物。此外，还提供了通过服用寡糖-蛋白共轭物治疗哺乳动物溶酶体贮积症的方法。
• SUBSTITUTED BENZOFURANYL AND BENZOXAZOLYL COMPOUNDS AND USES THEREOF
  申请人：Karyopharm Therapeutics Inc.

  公开号：US20190002448A1

  公开（公告）日：2019-01-03

  The invention generally relates to substituted benzofuranyl and substituted benzoxazolyl compounds, and more particularly to a compound represented by Structural Formula (I) or (II), or a pharmaceutically acceptable salt thereof, wherein the variables are as defined and described herein. The invention also includes the synthesis and use of a compound of Structural Formula A, or a pharmaceutically acceptable salt or composition thereof, e.g., in the treatment of cancer (e.g., mantle cell lymphoma), and other diseases and disorders.
• ORTHOGONAL PROTECTING GROUPS FOR THE PREPARATION OF STEREODEFINED PHOSPHOROTHIOATE OLIGONUCLEOTIDES
  申请人：Roche Innovation Center Copenhagen A/S

  公开号：US20210179658A1

  公开（公告）日：2021-06-17

  The present invention relates to the field of stereodefined phosphorothioate oligonucleotides and to stereodefining nucleoside monomers comprising an amine containing chiral auxiliary group, and methods of orthogonally protecting the nitrogen of chiral auxiliaries during oligonucleotide synthesis, preventing post elongation chain cleavage, increasing yield and purity of stereodefined phosphorothioate oligonucleotides.
• OLIGOSACCHARIDES COMPRISING AN AMINOOXY GROUP AND CONJUGATES THEREOF
  申请人：Genzyme Corporation

  公开号：US20220204963A1

  公开（公告）日：2022-06-30

  The invention provides methods for the synthesis of oligosaccharides comprising an aminooxy group. The invention further provides oligosaccharides comprising an aminooxy group, methods for coupling oligosaccharides comprising an aminooxy group to glycoproteins, and oligosaccharide-protein conjugates. Also provided are methods of treating a lysosomal storage disorder in a mammal by administration of an oligosaccharide-protein conjugate.