2,2-Dichloroethyl butanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2,2-Dichloroethyl butanoate
• 化学式: C₆H₁₀Cl₂O₂
• 分子量: 185.05
• InChiKey: DKRNAIVMRLUUJH-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  10
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• NOVEL CHROMENONE POTASSIUM CHANNEL BLOCKERS AND USES THEREOF
  申请人：Flynn Bernard Luke

  公开号：US20090298931A1

  公开（公告）日：2009-12-03

  The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of Kv1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

  本发明涉及化合物，可用于调节细胞中的钾通道活性，特别是调节T细胞中发现的Kv1.3通道的活性。本发明还涉及使用这些化合物治疗或预防自身免疫和炎症性疾病，包括多发性硬化症，含有这些化合物的制药组合物以及其制备方法。
• NOVEL BENZOFURAN POTASSIUM CHANNEL BLOCKERS AND USES THEREOF
  申请人：Flynn Bernard Luke

  公开号：US20100087430A1

  公开（公告）日：2010-04-08

  The present invention relates to compounds useful in the modulation of potassium channel activity in cells, in particular the activity of K v 1.3 channels found in T cells. The invention also relates to the use of these compounds in the treatment or prevention of autoimmune and inflammatory diseases, including multiple sclerosis, pharmaceutical compositions containing these compounds and methods for their preparation.

  本发明涉及化合物，其在细胞中调节钾通道活性方面具有用处，特别是调节T细胞中发现的Kv1.3通道活性。本发明还涉及使用这些化合物治疗或预防自身免疫性和炎症性疾病，包括多发性硬化症，含有这些化合物的制药组合物以及它们的制备方法。
• 1,4-Disubstituted-piperidinyl compounds
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0325268A1

  公开（公告）日：1989-07-26

  The present invention relates to 1,4-disubstituted-­piperdinyl compounds that have utility as analgesics and as muscle relaxants.

  本发明涉及 1,4-二取代哌啶基化合物，该化合物可用作镇痛剂和肌肉松弛剂。
• Process for the preparation of castanospermine esters
  申请人：MERRELL DOW PHARMACEUTICALS INC.

  公开号：EP0412487B1

  公开（公告）日：1994-12-28
• COMPOUND, AND SEPARATION METHOD, SYNTHESIS METHOD AND USE THEREOF
  申请人：Beijing Peking University WBL Biotech Co., Ltd.

  公开号：EP3255031B1

  公开（公告）日：2021-09-29