Propanamide, N,N-dihexyl-2,2-dimethyl-

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Propanamide, N,N-dihexyl-2,2-dimethyl-
• 英文别名: N,N-dihexyl-2,2-dimethylpropanamide
• 化学式: C₁₇H₃₅NO
• 分子量: 269.5
• InChiKey: HDBMDSBFRNAGDL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  19
• 可旋转键数：
  11
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  20.3
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• DELIVERY OF TARGET SPECIFIC NUCLEASES
  申请人：Sangamo Therapeutics, Inc.

  公开号：US20180185516A1

  公开（公告）日：2018-07-05

  Described herein are lipid nanoparticles comprising cationic lipids and other lipids and also comprising engineered nucleases facilitate transfer of nucleic acids to cells.
• LIPIDS FOR USE IN LIPID NANOPARTICLE FORMULATIONS
  申请人：ACUITAS THERAPEUTICS, INC.

  公开号：US20200172472A1

  公开（公告）日：2020-06-04

  Compounds are provided having the following structure (I) or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R 1a , R 1b , R 2a , R 2b , R 3a , R 3b , R 4a , R 4b , R 5 , R 6 , R 7 , R 8 , L 1 , L 2 , G 1 , G 2 , G 3 , a, b, c and d are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.